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Literature DB >> 30724944

Click and release: bioorthogonal approaches to "on-demand" activation of prodrugs.

Xingyue Ji¹, Zhixiang Pan², Bingchen Yu², Ladie Kimberly De La Cruz², Yueqin Zheng², Bowen Ke³, Binghe Wang².

Abstract

Prodrug approaches represent an excellent solution to certain pharmaceutical issues commonly encountered in the drug discovery and development process. Along this line, the chemistry needed for the bio-reversible derivatization of drug functional groups for on-demand release is critical. In recent years, "click and release" approaches have shown great promise in the design of prodrugs because of their bioorthogonality and controlled bond-cleavage, which help ensure prodrug stability during circulation and ready cleavage at the desired site of action. This review highlights recent developments of this research field and discusses issues yet to be addressed.

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Year: 2019 PMID： 30724944 DOI： 10.1039/c8cs00395e

Source DB: PubMed Journal: Chem Soc Rev ISSN： 0306-0012 Impact factor: 54.564

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Cited

38 in total

1. Tetrazine Carbon Nanotubes for Pretargeted In Vivo "Click-to-Release" Bioorthogonal Tumour Imaging.

Authors: He Li; João Conde; Ana Guerreiro; Gonçalo J L Bernardes
Journal: Angew Chem Int Ed Engl Date: 2020-08-07 Impact factor: 15.336

2. Fitness Factors for Bioorthogonal Chemical Probes.

Authors: Yulin Tian; Qing Lin
Journal: ACS Chem Biol Date: 2019-12-05 Impact factor: 5.100

3. Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation.

Authors: Bruno L Oliveira; Benjamin J Stenton; V B Unnikrishnan; Cátia Rebelo de Almeida; João Conde; Magda Negrão; Felipe S S Schneider; Carlos Cordeiro; Miguel Godinho Ferreira; Giovanni F Caramori; Josiel B Domingos; Rita Fior; Gonçalo J L Bernardes
Journal: J Am Chem Soc Date: 2020-06-09 Impact factor: 15.419

4. Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release.

Authors: Jeremy M Quintana; David Arboleda; Huiyu Hu; Ella Scott; Gaurav Luthria; Sara Pai; Sareh Parangi; Ralph Weissleder; Miles A Miller
Journal: Bioconjug Chem Date: 2022-07-14 Impact factor: 6.069

5. Co-delivery of 2-Deoxyglucose and a glutamine metabolism inhibitor V9302 via a prodrug micellar formulation for synergistic targeting of metabolism in cancer.

Authors: Zhangyi Luo; Jieni Xu; Jingjing Sun; Haozhe Huang; Ziqian Zhang; Weina Ma; Zhuoya Wan; Yangwuyue Liu; Apurva Pardeshi; Song Li
Journal: Acta Biomater Date: 2020-01-17 Impact factor: 8.947

Click and release: bioorthogonal approaches to "on-demand" activation of prodrugs.

1. Tetrazine Carbon Nanotubes for Pretargeted In Vivo "Click-to-Release" Bioorthogonal Tumour Imaging.

2. Fitness Factors for Bioorthogonal Chemical Probes.

3. Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation.

4. Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release.

5. Co-delivery of 2-Deoxyglucose and a glutamine metabolism inhibitor V9302 via a prodrug micellar formulation for synergistic targeting of metabolism in cancer.

6. Extracellular-Matrix-Anchored Click Motifs for Specific Tissue Targeting.

7. Bioorthogonal Retro-Cope Elimination Reaction of N,N-Dialkylhydroxylamines and Strained Alkynes.

8. Gold-Based Pharmacophore Inhibits Intracellular MYC Protein.

9. Dynamic pH responsivity of triazole-based self-immolative linkers.

Review 10. Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles.