| Literature DB >> 30717973 |
Ke Sun1, Zhankui Jia2, Ranran Duan3, Zechen Yan1, Zhibo Jin1, Liang Yan1, Qi Li1, Jinjian Yang4.
Abstract
Long non-coding RNAs (lncRNAs) have been demonstrated to exert important roles in cancer development and progression. The biological function of lncRNA X-inactive specific transcript (XIST) in the development of renal cell carcinoma (RCC) and the underlying mechanisms are still largely unknown. In this study, we found that XIST was down-regulated in RCC tissues and cells. Overexpression of XIST significantly suppressed cell proliferation and induced cell G0/G1 arrest in vitro and inhibited tumor growth in vivo. We further found that XIST could directly interact with miR-106b-5p and increase the expression of P21. Thus, XIST positively regulated the expression of P21 through sponging miR-106b-5p, and played a tumor suppressor role in RCC. Moreover, we found that curcumin could regulate XIST/miR-106b-5p/P21 axis in RCC cells. Our study exhibits the role of XIST as a miRNA sponge in RCC and supports the potential application of XIST in RCC therapy.Entities:
Keywords: Cell proliferation; Curcumin; P21; XIST; miR-106b-5p
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Year: 2019 PMID： 30717973 DOI： 10.1016/j.bbrc.2019.01.116
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575