| Literature DB >> 30716903 |
Ju Young Eor1, Pei Lei Tan1, Sei Mi Lim1, Da Hye Choi2, Seok Min Yoon2, Si Young Yang2, Sae Hun Kim3.
Abstract
The fecal morphology, defecation frequency, bowel function, intestinal motility, and fecal bacterial composition were evaluated to investigate the laxative effect of probiotic chocolate containing Streptococcus thermophilus MG510 and Lactobacillus plantarum LRCC5193 (LYC) on loperamide-induced constipated rats. Daily oral administration of LYC in constipated rats for two weeks was shown to significantly increase (n = 14) the defecation frequency, fecal moisture content, and relative abundance of fecal Lactobacillus and Faecalibacterium prausnitzii. Moreover, histological analysis of the distal colon of constipated rats revealed that LYC treatment can also increase the thickness of the colonic mucosa and muscle layers, and crypt of Lieberkühn. LYC also significantly increased (n = 5) the intestinal motility and modulated (n = 9) mRNA expression levels of colonic ZO-1 and Cldn-1 in the constipated rats. Altogether, these results demonstrate that probiotic chocolate has potential as a dietary adjunct for the treatment of constipation.Entities:
Keywords: Constipation; Gastrointestinal health; Lactobacillus plantarum LRCC5193; Probiotic chocolate; Streptococcus thermophilus MG510
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Year: 2018 PMID： 30716903 DOI： 10.1016/j.foodres.2018.09.062
Source DB: PubMed Journal: Food Res Int ISSN： 0963-9969 Impact factor: 6.475