Jiangtao Zhu1, Ningfan Hu2, Xiaoyun Liang3, Xiaojing Li2, Jian Guan4,5,6, Yajuan Wang4,5,6, Ligong Wang4,5,6. 1. Department of Radiology, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou, 215004, Jiangsu Province, China. jiangtaozhu@126.com. 2. Department of Radiology, The Second Affiliated Hospital of Soochow University, 1055 San Xiang Road, Suzhou, 215004, Jiangsu Province, China. 3. Florey Institute of Neuroscience and Mental Health, 245 Burgundy Street, Heidelberg, VIC, 3084, Australia. 4. Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Bldg. 402, 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, 215123, Jiangsu Province, China. 5. School of Radiation Medicine and Protection, Medical College of Soochow University, Bldg. 402, 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, 215123, Jiangsu Province, China. 6. School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Bldg. 402, 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, 215123, Jiangsu Province, China.
Abstract
PURPOSE: To assess the relationship between knee alignment and T2 values of femorotibial cartilage and menisci in healthy subjects at 3 T. MATERIALS AND METHODS: Thirty-six healthy subjects divided into three subgroups of 12 neutral, 12 varus, and 12 valgus alignment of the femorotibial joint were investigated on 3-T MR scanner using a 2D multi-echo turbo spin-echo (TSE) sequence for T2 mapping. Wilcoxon signed-rank test and analysis of covariance (ANCOVA) were performed to determine any statistically significant differences in subregional T2 values of femorotibial cartilage and menisci among the three subgroups of healthy subjects. RESULTS: Lateral femoral anterior cartilage subregion (52 ± 3 ms, mean ± standard deviation; 53 ± 2 ms) had significantly higher T2 values (p < 0.05) than medial femoral anterior cartilage subregion (51 ± 2 ms; 51 ± 2 ms) in varus and valgus groups, respectively. There were statistically significant differences (p < 0.05) in T2 values of tibial central cartilage subregion between lateral and medical compartment among varus, valgus, and neutral subgroups. Lateral body segment of meniscus (41 ± 3 ms) had significantly higher (p < 0.05) T2 values than medial body segment (40 ± 2 ms) in the varus subgroup. CONCLUSIONS: Some degree of correlation between knee alignment and subregional T2 values of femorotibial cartilage and menisci exists in healthy subjects. These findings indicate that T2 mapping may be sensitive in assessing the load distribution pattern of human cartilage and menisci with knee alignment abnormality, which may be used as reference baseline when understanding the occurrence and progression of knee osteoarthritis.
PURPOSE: To assess the relationship between knee alignment and T2 values of femorotibial cartilage and menisci in healthy subjects at 3 T. MATERIALS AND METHODS: Thirty-six healthy subjects divided into three subgroups of 12 neutral, 12 varus, and 12 valgus alignment of the femorotibial joint were investigated on 3-T MR scanner using a 2D multi-echo turbo spin-echo (TSE) sequence for T2 mapping. Wilcoxon signed-rank test and analysis of covariance (ANCOVA) were performed to determine any statistically significant differences in subregional T2 values of femorotibial cartilage and menisci among the three subgroups of healthy subjects. RESULTS: Lateral femoral anterior cartilage subregion (52 ± 3 ms, mean ± standard deviation; 53 ± 2 ms) had significantly higher T2 values (p < 0.05) than medial femoral anterior cartilage subregion (51 ± 2 ms; 51 ± 2 ms) in varus and valgus groups, respectively. There were statistically significant differences (p < 0.05) in T2 values of tibial central cartilage subregion between lateral and medical compartment among varus, valgus, and neutral subgroups. Lateral body segment of meniscus (41 ± 3 ms) had significantly higher (p < 0.05) T2 values than medial body segment (40 ± 2 ms) in the varus subgroup. CONCLUSIONS: Some degree of correlation between knee alignment and subregional T2 values of femorotibial cartilage and menisci exists in healthy subjects. These findings indicate that T2 mapping may be sensitive in assessing the load distribution pattern of humancartilage and menisci with knee alignment abnormality, which may be used as reference baseline when understanding the occurrence and progression of knee osteoarthritis.
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