| Literature DB >> 30711206 |
Georgia Malamut1, Christophe Cellier2.
Abstract
Refractory celiac disease (RCD) refers to persistence of malnutrition and intestinal villous atrophy for more than 1 to 2 years despite strict gluten-free diet in patients with celiac disease. Diagnosis remains difficult and impacts treatment and follow-up. RCD has been subdivided into 2 subgroups according to the normal (RCDI) or abnormal phenotype of intraepithelial lymphocytes (IELs) (RCDII). RCDII is considered as a low-grade intraepithelial lymphoma and has a poor prognosis due to gastrointestinal and extraintestinal dissemination of the abnormal IELs, and high risk of overt lymphoma.Entities:
Keywords: Cytokine IL-15; Enteropathy-associated T-cell lymphoma; Phenotype of intraepithelial lymphocytes; Refractory celiac disease
Mesh:
Substances:
Year: 2018 PMID: 30711206 DOI: 10.1016/j.gtc.2018.09.010
Source DB: PubMed Journal: Gastroenterol Clin North Am ISSN: 0889-8553 Impact factor: 3.806