| Literature DB >> 30703615 |
César Prado1, Paula Fratini2, Gustavo de Sá Schiavo Matias2, Renato Z Bocabello3, Juliana Monteiro3, Célio J Dos Santos4, Jean G F Joaquim5, Robson F Giglio6, Fabio S Possebon7, Stella H Sakata8, Maria A Miglino1.
Abstract
Spinal cord injury (SCI) is a serious condition that causes profound economic and emotional impact in human patients and companion animal owners. It has been shown that the neurogenic effects of the stem cells are enhanced when combined with electroacupuncture (EA) in rodent models of SCI. To determine the safety and feasibility of combining transplantation of allogenic stem cells derived from canine exfoliated deciduous teeth (SCED) and EA in dogs with chronic spinal cord injury a canine pilot clinical study was conducted. A total of 16 individuals ranging from 5 to 11 years at 3 to 18 months of injury were investigated and randomly assigned to 4 experimental groups (SCED, EA, SCED + EA, control). Mild neurological and functional improvements were seen in all 4 groups. There was no clinical progression or mortality of the cases occurred in a follow up of 7 months after procedure. The study shows that SCED transplantation and electroacupuncture were feasible, safe and potentially beneficial. However Long-term patient monitoring is necessary to rule out any delayed side effects and assess any further improvements.Entities:
Keywords: Cell therapy; Electroacupuncture; Intervertebral disc disease; Intervertebral disc herniation; Stem cells from exfoliated human dental pulp
Mesh：
Year: 2019 PMID： 30703615 DOI： 10.1016/j.rvsc.2019.01.011
Source DB: PubMed Journal: Res Vet Sci ISSN： 0034-5288 Impact factor: 2.534