Wei Zhu1, Jimin Guo1, Yi Ju2, Rita E Serda3, Jonas G Croissant1, Jin Shang4, Eric Coker5, Jacob Ongudi Agola1, Qi-Zhi Zhong2, Yuan Ping6, Frank Caruso2, C Jeffrey Brinker1. 1. Center for Micro-Engineered Materials, Department of Chemical and Biological Engineering, The University of New Mexico, Albuquerque, NM, 87131, USA. 2. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and The Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia. 3. Department of Internal Medicine, Molecular Medicine, The University of New Mexico, Albuquerque, NM, 87131, USA. 4. School of Energy and Environment, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, P. R. China. 5. Sandia National Laboratories, Applied Optical/Plasma Sciences, P.O. Box 5800, MS 1411, Albuquerque, NM, 87185-1411, USA. 6. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, P. R. China.
Abstract
Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superassembly of nanosized metal-organic polyhedra (MOP) and their biomimetic coatings of lipid bilayers are described to synergistically combine the advantages of micelles and supramolecular coordination cages for targeted drug delivery. The superassembly technique affords unique hydrophobic features that endow individual MOP to act as nanobuilding blocks and enable their superassembly into larger and well-defined nanocarriers with homogeneous sizes over a broad range of diameters. Various cargos are controllably loaded into the MOP with high payloads, and the nanocages are then superassembled to form multidrug delivery systems. Additionally, functional nanoparticles are introduced into the superassemblies via a one-pot process for versatile bioapplications. The MOP superassemblies are surface-engineered with epidermal growth factor receptors and can be targeted to cancer cells. In vivo studies indicated the assemblies to have a substantial circulation half-life of 5.6 h and to undergo renal clearance-characteristics needed for nanomedicines.
Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superassembly of nanosized metal-organic polyhedra (n class="Chemical">MOP) and their biomimetic coatings of lipid bilayers are described to synergistically combine the advantages of micelles and supramolecular coordination cages for targeted drug delivery. The superassembly technique affords unique hydrophobic features that endow individual MOP to act as nanobuilding blocks and enable their superassembly into larger and well-defined nanocarriers with homogeneous sizes over a broad range of diameters. Various cargos are controllably loaded into the MOP with high payloads, and the nanocages are then superassembled to form multidrug delivery systems. Additionally, functional nanoparticles are introduced into the superassemblies via a one-pot process for versatile bioapplications. The MOP superassemblies are surface-engineered with epidermal growth factor receptors and can be targeted to cancer cells. In vivo studies indicated the assemblies to have a substantial circulation half-life of 5.6 h and to undergo renal clearance-characteristics needed for nanomedicines.
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