Literature DB >> 30696697

TERT gene: its function and dysregulation in cancer.

Andrew J Colebatch1, Alexander Dobrovic2,3,4,5, Wendy A Cooper6,7,8.   

Abstract

In this review, we summarise the function and structure of telomerase reverse transcriptase (TERT) in humans, including its regulation. The dysregulation of telomerase through TERT promoter mutations across a range of cancers is discussed. The molecular mechanism activated by TERT promoter mutations is outlined. Finally, the timing of TERT promoter mutations during carcinogenesis is reviewed in the context of their potential utility as clinical biomarkers of malignant transformation. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  cancer; cancer genetics; cancer research

Mesh：

Substances：

Year:  2019        PMID： 30696697     DOI： 10.1136/jclinpath-2018-205653

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  20 in total

Review 1.  Human TERT promoter polymorphism rs2853669 is associated with cancers: an updated meta-analysis.

Authors:  Md Abdul Aziz; Sarah Jafrin; Mohammad Safiqul Islam
Journal:  Hum Cell       Date:  2021-03-20       Impact factor: 4.174

2.  TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer.

Authors:  Neeraj Agarwal; Sebastien Rinaldetti; Bassem B Cheikh; Qiong Zhou; Evan P Hass; Robert T Jones; Molishree Joshi; Daniel V LaBarbera; Simon R V Knott; Thomas R Cech; Dan Theodorescu
Journal:  Proc Natl Acad Sci U S A       Date:  2021-09-21       Impact factor: 11.205

3.  Mutational Characteristics of Primary Mucosal Melanoma: A Systematic Review.

Authors:  Olivia Beaudoux; Jean-Baptiste Oudart; Laurence Riffaud; Laetitia Visseaux; Aude Marchal; Anne-Sophie Lebre; Florent Grange
Journal:  Mol Diagn Ther       Date:  2022-02-23       Impact factor: 4.074

Review 4.  Correlation of molecular alterations with pathological features in hepatocellular carcinoma: Literature review and experience of an Italian center.

Authors:  Thais Maloberti; Antonio De Leo; Viviana Sanza; Elisa Gruppioni; Annalisa Altimari; Mattia Riefolo; Michela Visani; Deborah Malvi; Antonia D'Errico; Giovanni Tallini; Francesco Vasuri; Dario de Biase
Journal:  World J Gastroenterol       Date:  2022-07-07       Impact factor: 5.374

Review 5.  Cell senescence and malignant transformation in the inherited bone marrow failure syndromes: Overlapping pathophysiology with therapeutic implications.

Authors:  Emma M Groarke; Rodrigo T Calado; Johnson M Liu
Journal:  Semin Hematol       Date:  2022-01-31       Impact factor: 3.754

6.  LPCAT1-TERT fusions are uniquely recurrent in epithelioid trophoblastic tumors and positively regulate cell growth.

Authors:  Gavin R Oliver; Sofia Marcano-Bonilla; Jonathan Quist; Ezequiel J Tolosa; Eriko Iguchi; Amy A Swanson; Nicole L Hoppman; Tanya Schwab; Ashley Sigafoos; Naresh Prodduturi; Jesse S Voss; Shannon M Knight; Jin Zhang; Numrah Fadra; Raul Urrutia; Michael Zimmerman; Jan B Egan; Anthony G Bilyeu; Jin Jen; Ema Veras; Rema'a Al-Safi; Matthew Block; Sarah Kerr; Martin E Fernandez-Zapico; John K Schoolmeester; Eric W Klee
Journal:  PLoS One       Date:  2021-05-25       Impact factor: 3.240

Review 7.  Current Advances on the Important Roles of Enhancer RNAs in Molecular Pathways of Cancer.

Authors:  Rui Wang; Qianzi Tang
Journal:  Int J Mol Sci       Date:  2021-05-26       Impact factor: 5.923

8.  Molecular Genetics of Conjunctival Melanoma and Prognostic Value of TERT Promoter Mutation Analysis.

Authors:  Natasha M van Poppelen; Jolique A van Ipenburg; Quincy van den Bosch; Jolanda Vaarwater; Tom Brands; Bert Eussen; Frank Magielsen; Hendrikus J Dubbink; Dion Paridaens; Erwin Brosens; Nicole Naus; Annelies de Klein; Emine Kiliç; Robert M Verdijk
Journal:  Int J Mol Sci       Date:  2021-05-28       Impact factor: 5.923

9.  Progression of Papillary Thyroid Carcinoma to Anaplastic Carcinoma in Metastatic Lymph Nodes: Solid/Insular Growth and Hobnail Cell Change in Lymph Nodes Are Predictors of Subsequent Anaplastic Transformation.

Authors:  Toru Odate; Naoki Oishi; Masataka Kawai; Ippei Tahara; Kunio Mochizuki; Junko Akaishi; Koichi Ito; Ryohei Katoh; Tetsuo Kondo
Journal:  Endocr Pathol       Date:  2021-03-24       Impact factor: 3.943

10.  TERT Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas.

Authors:  Leonora Balaj; Bob S Carter; Koushik Muralidharan; Anudeep Yekula; Julia L Small; Zachary S Rosh; Keiko M Kang; Lan Wang; Spencer Lau; Hui Zhang; Hakho Lee; Chetan Bettegowda; Michael R Chicoine; Steven N Kalkanis; Ganesh M Shankar; Brian V Nahed; William T Curry; Pamela S Jones; Daniel P Cahill
Journal:  Clin Cancer Res       Date:  2020-10-13       Impact factor: 13.801
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