I-Kuan Wang1,2, Tsung-Hsun Tsai3,4, Yi-Chih Hung5, Tzu-Yuan Wang5, Tzung-Hai Yen6,7, Cheng-Li Lin6, Fung-Chang Sung8,9,10. 1. Department of Internal Medicine, College of Medicine, China Medical University, Taichung, Taiwan. 2. Division of Nephrology, China Medical University Hospital, Taichung, Taiwan. 3. Graduate Institute of Clinical Medical Science, China Medical University College of Medicine, Taichung, Taiwan. 4. Division of Urology, Department of Surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan. 5. Division of Endocrinology, China Medical University Hospital, Taichung, Taiwan. 6. Division of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan. 7. Chang Gung University College of Medicine, Taoyuan, Taiwan. 8. Graduate Institute of Clinical Medical Science, China Medical University College of Medicine, Taichung, Taiwan. fcsung1008@yahoo.com. 9. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan. fcsung1008@yahoo.com. 10. Department of Health Services Administration, China Medical University, 91 Hsueh Shih Road, Taichung, 404, Taiwan. fcsung1008@yahoo.com.
Abstract
PURPOSE: This study investigated whether people with chronic kidney disease (CKD) are at the risk of new-onset type 2 diabetes. METHODS: A cohort comprising 16,624 people with CKD, and an age- and sex-matched control cohort of 66,496 persons without any clinical kidney disease were identified from the Taiwan National Health Insurance Database during the period of 2000-2010. Both cohorts were followed up to 2011 to evaluate the incidence and hazard ratio (HR) of developing new-onset type 2 diabetes. Diseases were identified based on diagnosis coding. RESULTS: The incidence of type 2 diabetes was 1.51-fold higher in the CKD cohort than in the control cohort (16.9 versus 11.2 per 1,000 person-years) with an adjusted hazard ratio of 1.17 (95% confidence interval, (CI)1.10-1.24). In the multivariate Cox regression model considering the competing-risk death, the adjusted subhazard ratio of type 2 diabetes was 1.30 (95% CI1.22-1.38) for the CKD cohort compared to the control cohort. CONCLUSIONS: People with CKD patients are at an increased risk of developing new-onset type 2 diabetes. Close surveillance for diabetes should be considered for these people.
PURPOSE: This study investigated whether people with chronic kidney disease (CKD) are at the risk of new-onset type 2 diabetes. METHODS: A cohort comprising 16,624 people with CKD, and an age- and sex-matched control cohort of 66,496 persons without any clinical kidney disease were identified from the Taiwan National Health Insurance Database during the period of 2000-2010. Both cohorts were followed up to 2011 to evaluate the incidence and hazard ratio (HR) of developing new-onset type 2 diabetes. Diseases were identified based on diagnosis coding. RESULTS: The incidence of type 2 diabetes was 1.51-fold higher in the CKD cohort than in the control cohort (16.9 versus 11.2 per 1,000 person-years) with an adjusted hazard ratio of 1.17 (95% confidence interval, (CI)1.10-1.24). In the multivariate Cox regression model considering the competing-risk death, the adjusted subhazard ratio of type 2 diabetes was 1.30 (95% CI1.22-1.38) for the CKD cohort compared to the control cohort. CONCLUSIONS:People with CKDpatients are at an increased risk of developing new-onset type 2 diabetes. Close surveillance for diabetes should be considered for these people.
Authors: Jing Chen; Paul Muntner; L Lee Hamm; Vivian Fonseca; Vecihi Batuman; Paul K Whelton; Jiang He Journal: J Am Soc Nephrol Date: 2003-02 Impact factor: 10.121