Li Fan1, QingChu Li1, WenTing Tu1, RuTan Chen1, Yi Xia1, Yu Pu1, ZhaoBin Li2, ShiYuan Liu3. 1. Department of Radiology, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai, 200003, China. 2. Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600 Yishan Road, Shanghai, 200233, China. lizhaobin79@163.com. 3. Department of Radiology, Changzheng Hospital, Second Military Medical University, No. 415 Fengyang Road, Shanghai, 200003, China. lsy0930@163.com.
Abstract
OBJECTIVE: To evaluate quantitative parameters of nonsolid nodules on paired inspiratory and expiratory computed tomography (CT) and to examine whether these parameters are sensitive to lung inflation reflected by lung volume. METHODS: Thirty-three patients with 41 nonsolid nodules were included in this prospective study. Paired inspiratory and low-dose respiratory plain chest CT were performed. The volume and density of nonsolid nodule(s), both lungs, the right and left lung, and five lobes, were analyzed in inspiratory and expiratory CT scans. The ratio of expiratory to inspiratory parameters was calculated and labeled as parameter(E-I)/I. To standardize the changes in nonsolid nodule quantitative parameters, the ratio of nonsolid nodule parameter to lung parameter was also calculated. Quantitative parameters were compared between inspiratory and expiratory CT. RESULTS: Nonsolid nodule volumes on expiratory CT were reduced by 19.8% ± 12.9%, while the density was increased by 11.4% ± 8.8%. The volume of nonsolid nodules was significantly greater on inspiratory compared with expiratory CT (p < 0.001). The density of nonsolid nodules was significantly greater on expiratory than inspiratory CT (p < 0.001). The volume(E-I)/I was significantly greater than density(E-I)/I both in nonsolid nodules and lung. The volume(E-I)/I and density(E-I)/I of nonsolid nodules were independent of size. The density(E-I)/I of nonsolid nodule was greater in the lower lobe than that in the upper lobe (p = 0.002). CONCLUSION: Volume changes in nonsolid nodules were more sensitive than density changes in expiratory phase. The density of lower lobe nodules was more susceptible to respiration. Expiratory scanning is not recommended for quantification of nonsolid nodules and/or follow-up. KEY POINTS: • The nonsolid nodule volume on expiratory CT was reduced by 19.8% ± 12.9%. • The nonsolid nodule density on expiratory CT was increased by 11.4% ± 8.8%. • The volume (E-I)/I and density (E-I)/I of nonsolid nodules were independent of size.
OBJECTIVE: To evaluate quantitative parameters of nonsolid nodules on paired inspiratory and expiratory computed tomography (CT) and to examine whether these parameters are sensitive to lung inflation reflected by lung volume. METHODS: Thirty-three patients with 41 nonsolid nodules were included in this prospective study. Paired inspiratory and low-dose respiratory plain chest CT were performed. The volume and density of nonsolid nodule(s), both lungs, the right and left lung, and five lobes, were analyzed in inspiratory and expiratory CT scans. The ratio of expiratory to inspiratory parameters was calculated and labeled as parameter(E-I)/I. To standardize the changes in nonsolid nodule quantitative parameters, the ratio of nonsolid nodule parameter to lung parameter was also calculated. Quantitative parameters were compared between inspiratory and expiratory CT. RESULTS: Nonsolid nodule volumes on expiratory CT were reduced by 19.8% ± 12.9%, while the density was increased by 11.4% ± 8.8%. The volume of nonsolid nodules was significantly greater on inspiratory compared with expiratory CT (p < 0.001). The density of nonsolid nodules was significantly greater on expiratory than inspiratory CT (p < 0.001). The volume(E-I)/I was significantly greater than density(E-I)/I both in nonsolid nodules and lung. The volume(E-I)/I and density(E-I)/I of nonsolid nodules were independent of size. The density(E-I)/I of nonsolid nodule was greater in the lower lobe than that in the upper lobe (p = 0.002). CONCLUSION: Volume changes in nonsolid nodules were more sensitive than density changes in expiratory phase. The density of lower lobe nodules was more susceptible to respiration. Expiratory scanning is not recommended for quantification of nonsolid nodules and/or follow-up. KEY POINTS: • The nonsolid nodule volume on expiratory CT was reduced by 19.8% ± 12.9%. • The nonsolid nodule density on expiratory CT was increased by 11.4% ± 8.8%. • The volume (E-I)/I and density (E-I)/I of nonsolid nodules were independent of size.
Authors: David P Naidich; Alexander A Bankier; Heber MacMahon; Cornelia M Schaefer-Prokop; Massimo Pistolesi; Jin Mo Goo; Paolo Macchiarini; James D Crapo; Christian J Herold; John H Austin; William D Travis Journal: Radiology Date: 2012-10-15 Impact factor: 11.105
Authors: Tsuneo Yamashiro; Shin Matsuoka; Brian J Bartholmai; Raúl San José Estépar; James C Ross; Alejandro Diaz; Sadayuki Murayama; Edwin K Silverman; Hiroto Hatabu; George R Washko Journal: Acad Radiol Date: 2010-01-12 Impact factor: 3.173
Authors: Craig P Hersh; George R Washko; Raúl San José Estépar; Sharon Lutz; Paul J Friedman; MeiLan K Han; John E Hokanson; Philip F Judy; David A Lynch; Barry J Make; Nathaniel Marchetti; John D Newell; Frank C Sciurba; James D Crapo; Edwin K Silverman Journal: Respir Res Date: 2013-04-08