Yılmaz Bülbül1, Tevfik Özlü1, Sibel Arınç2, Berna Akıncı Özyürek3, Hülya Günbatar4, Ayşegül Şentürk3, Ayşe Bahadır5, Melike Özçelik6, Ufuk Yılmaz7, Makbule Ö Akbay2, Leyla Sağlam8, Talat Kılıç9, Gamze Kırkıl10, Neslihan Özçelik1, Dursun Alizoroğlu7, Serap Argun Barış11, Durdu M Yavşan12, Hadice S Şen13, Serdar Berk14, Murat Acat15, Gülfidan Çakmak16, Perran F Yumuk17, Yavuz Selim İntepe18, Ümran Toru19, Sibel Öktem Ayık20, İlknur Başyiğit11, Sibel Özkurt21, Levent C Mutlu22, Zehra Yaşar23, Hıdır Esme24, Mehmet M Erol25, Özlem Oruç2, Yurdanur Erdoğan3, Selvi Asker4, Arife Ulaş26, Serhat Erol7, Buğra Kerget8, Ahmet Emin Erbaycu7, Turgut Teke12, Mehmet Beşiroğlu17, Hüseyin Can27, Ayşe Dallı20, Fahrettin Talay23. 1. Department of Chest Diseases, Farabi Hospital, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. 2. Clinic of Chest Diseases, Istanbul Sureyyapasa Chest Diseases and Chest Surgery Training and Research Hospital, Istanbul, Turkey. 3. Clinic of Chest Diseases, Ankara Ataturk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey. 4. Department of Chest Diseases, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey. 5. Clinic of Chest Diseases, Istanbul Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Istanbul, Turkey. 6. Division of Medical Oncology, Istanbul Lutfi Kırdar Kartal Training and Research Hospital, Istanbul, Turkey. 7. Clinic of Chest Diseases, Izmir Dr. Suat Seren Chest Diseases and Chest Surgery Training and Research Hospital, Izmir, Turkey. 8. Department of Chest Diseases, Faculty of Medicine, Ataturk University, Erzurum, Turkey. 9. Department of Chest Diseases, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey. 10. Department of Chest Diseases, Faculty of Medicine, Fırat University, Elazig, Turkey. 11. Department of Chest Diseases, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. 12. Department of Chest Diseases, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey. 13. Department of Chest Diseases, Faculty of Medicine, Dicle University, Diyarbakır, Turkey. 14. Department of Chest Diseases, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey. 15. Department of Chest Diseases, Faculty of Medicine, Karabuk University, Karabuk, Turkey. 16. Clinic of Chest Diseases, Istanbul Haseki Training and Research Hospital, Istanbul, Turkey. 17. Division of Medical Oncology, Faculty of Medicine, Marmara University, Istanbul, Turkey. 18. Department of Chest Diseases, Faculty of Medicine Bozok University, Yozgat, Turkey. 19. Department of Chest Diseases, Faculty of Medicine, Dumlupinar University, Kutahya, Turkey. 20. Department of Chest Diseases, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey. 21. Department of Chest Diseases, Faculty of Medicine, Pamukkale University, Denizli, Turkey. 22. Department of Chest Diseases, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey. 23. Department of Chest Diseases, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu, Turkey. 24. Clinic of Thoracic Surgery, Meram Training and Research Hospital, Konya, Turkey. 25. Department of Thoracic Surgery, Faculty of Medicine, Uludag University, Bursa, Turkey. 26. Clinic of Medical Oncology, Atatürk Education and Research Hospital, Ankara, Turkey. 27. Department of Family Medicine, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey.
Abstract
INTRODUCTION: Sleep quality is known to be associated with the distressing symptoms of cancer. The purpose of this study was to analyze the impact of cancer symptoms on insomnia and the prevalence of sleep-related problems reported by the patients with lung cancer in Turkey. MATERIALS AND METHODS: Assesment of Palliative Care in Lung Cancer in Turkey (ASPECT) study, a prospective multicenter study conducted in Turkey with the participation of 26 centers and included all patients with lung cancer, was re-evaluated in terms of sleep problems, insomnia and possible association with the cancer symptoms. Demographic characteristics of patients and information about disease were recorded for each patient by physicians via face-to-face interviews, and using hospital records. Patients who have difficulty initiating or maintaining sleep (DIMS) is associated with daytime sleepiness/fatigue were diagnosed as having insomnia. Daytime sleepiness, fatigue and lung cancer symptoms were recorded and graded using the Edmonton Symptom Assessment Scale. RESULT: Among 1245 cases, 48.4% reported DIMS, 60.8% reported daytime sleepiness and 82.1% reported fatigue. The prevalence of insomnia was 44.7%. Female gender, patients with stage 3-4 disease, patients with metastases, with comorbidities, and with weight loss > 5 kg had higher rates of insomnia. Also, patients with insomnia had significantly higher rates of pain, nausea, dyspnea, and anxiety. Multivariate logistic regression analysis showed that patients with moderate to severe pain and dyspnea and severe anxiety had 2-3 times higher rates of insomnia. CONCLUSIONS: In conclusion, our results showed a clear association between sleep disturbances and cancer symptoms. Because of that, adequate symptom control is essential to maintain sleep quality in patients with lung cancer.
INTRODUCTION: Sleep quality is known to be associated with the distressing symptoms of cancer. The purpose of this study was to analyze the impact of cancer symptoms on insomnia and the prevalence of sleep-related problems reported by the patients with lung cancer in Turkey. MATERIALS AND METHODS: Assesment of Palliative Care in Lung Cancer in Turkey (ASPECT) study, a prospective multicenter study conducted in Turkey with the participation of 26 centers and included all patients with lung cancer, was re-evaluated in terms of sleep problems, insomnia and possible association with the cancer symptoms. Demographic characteristics of patients and information about disease were recorded for each patient by physicians via face-to-face interviews, and using hospital records. Patients who have difficulty initiating or maintaining sleep (DIMS) is associated with daytime sleepiness/fatigue were diagnosed as having insomnia. Daytime sleepiness, fatigue and lung cancer symptoms were recorded and graded using the Edmonton Symptom Assessment Scale. RESULT: Among 1245 cases, 48.4% reported DIMS, 60.8% reported daytime sleepiness and 82.1% reported fatigue. The prevalence of insomnia was 44.7%. Female gender, patients with stage 3-4 disease, patients with metastases, with comorbidities, and with weight loss > 5 kg had higher rates of insomnia. Also, patients with insomnia had significantly higher rates of pain, nausea, dyspnea, and anxiety. Multivariate logistic regression analysis showed that patients with moderate to severe pain and dyspnea and severe anxiety had 2-3 times higher rates of insomnia. CONCLUSIONS: In conclusion, our results showed a clear association between sleep disturbances and cancer symptoms. Because of that, adequate symptom control is essential to maintain sleep quality in patients with lung cancer.
Authors: Dirk Rades; Svenja Kopelke; Soeren Tvilsted; Troels W Kjaer; Steven E Schild; Tobias Bartscht Journal: In Vivo Date: 2021 Nov-Dec Impact factor: 2.155