Thierry Morlet1,2,3, Kyoko Nagao1,2,4, L Ashleigh Greenwood1, R Matthew Cardinale1, Rebecca G Gaffney1, Tammy Riegner5. 1. a Auditory Physiology and Psychoacoustics Research Laboratory , Center for Pediatric Auditory Speech and Sciences, Nemours/Alfred I. duPont Hospital for Children , Wilmington , DE , USA. 2. b Department of Linguistics and Cognitive Science, College of Arts & Science , University of Delaware , Newark , DE , USA. 3. c Georges Osborne College of Audiology , Salus University , Elkins Park , PA , USA. 4. d Communication Sciences and Disorders, College of Health Science , University of Delaware , Newark , DE , USA. 5. e Department of Audiology , Nemours/Alfred I. duPont Hospital for Children , Wilmington , DE , USA.
Abstract
OBJECTIVE: The objectives were to investigate the function of central auditory pathways and of the medial efferent olivocochlear system (MOCS). DESIGN: Event-related potentials (ERP) were recorded following the delivery of the stimulus /da/ in quiet and in ipsilateral, contralateral, and binaural noise conditions and correlated to the results of the auditory processing disorders (APD) diagnostic test battery. MOCS function was investigated by adding ipsilateral, contralateral, and binaural noise to transient evoked otoacoustic emission recordings. Auditory brainstem responses and pure tone audiogram were also evaluated. STUDY SAMPLE: Nineteen children (7 to 12 years old) with APD were compared with 24 age-matched controls. RESULTS: Otoacoustic emissions and ABR characteristics did not differ between groups, whereas ERP latencies were significantly longer and of higher amplitudes in APD children than in controls, in both quiet and noise conditions. The MOCS suppression was higher in APD children. CONCLUSIONS: Findings indicate that children with APD present with neural deficiencies in both challenging and nonchallenging environments with an increase in the timing of several central auditory processes correlated to their behavioural performances. Meanwhile, their modulation of the auditory periphery under noisy conditions differs from control children with higher suppression.
OBJECTIVE: The objectives were to investigate the function of central auditory pathways and of the medial efferent olivocochlear system (MOCS). DESIGN: Event-related potentials (ERP) were recorded following the delivery of the stimulus /da/ in quiet and in ipsilateral, contralateral, and binaural noise conditions and correlated to the results of the auditory processing disorders (APD) diagnostic test battery. MOCS function was investigated by adding ipsilateral, contralateral, and binaural noise to transient evoked otoacoustic emission recordings. Auditory brainstem responses and pure tone audiogram were also evaluated. STUDY SAMPLE: Nineteen children (7 to 12 years old) with APD were compared with 24 age-matched controls. RESULTS: Otoacoustic emissions and ABR characteristics did not differ between groups, whereas ERP latencies were significantly longer and of higher amplitudes in APDchildren than in controls, in both quiet and noise conditions. The MOCS suppression was higher in APDchildren. CONCLUSIONS: Findings indicate that children with APD present with neural deficiencies in both challenging and nonchallenging environments with an increase in the timing of several central auditory processes correlated to their behavioural performances. Meanwhile, their modulation of the auditory periphery under noisy conditions differs from control children with higher suppression.
Authors: Uzma S Wilson; Kate M Sadler; Kenneth E Hancock; John J Guinan; Jeffery T Lichtenhan Journal: J Neurophysiol Date: 2017-06-07 Impact factor: 2.714