| Literature DB >> 30678973 |
Duoguang Wu1, Wenjian Wang1, Xiaotian He1, Ming Jiang2, Cuiping Lai3, Xueting Hu1, Jingle Xi4, Minghui Wang5.
Abstract
Copper oxide nanoparticles (CuO NPs) are fabricated using Coleus aromaticus leaf extract with an environmental friendly method and studied using various microscopic and spectroscopic techniques. Also, a new aptamer-conjugated hybrid delivery system using green synthesized CuO NPs is developed to deliver miRNA-29b to A549 cells. This delivery system can effectively deliver miRNAs to cancer cells, with superior performance compared to traditionally available transfection agents, thus acting as an efficient platform for intracellular miRNA delivery and improving therapeutic outcomes for lung cancer.Entities:
Keywords: A549 cells; Coleus aromaticus; CuO NPs; Drug delivery; in-vitro cytotoxicity; miRNA
Mesh：
Substances：
Year: 2018 PMID： 30678973 DOI： 10.1016/j.msec.2018.12.009
Source DB: PubMed Journal: Mater Sci Eng C Mater Biol Appl ISSN： 0928-4931 Impact factor: 7.328