Davy Vancampfort1,2, Brendon Stubbs3,4,5, Joseph Firth6,7, Lee Smith8, Nathalie Swinnen1,2, Ai Koyanagi9,10,11. 1. Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium. 2. University Psychiatric Center, KU Leuven, Kortenberg, Belgium. 3. Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London, UK. 4. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. 5. Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford, UK. 6. NICM Health Research Institute, School of Science and Health, University of Western Sydney, Sydney, Australia. 7. Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. 8. Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia. 9. The Cambridge Centre for Sport and Exercise Sciences, Department of Life Sciences, Anglia Ruskin University, Cambridge, UK. 10. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. 11. Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Barcelona, Spain.
Abstract
OBJECTIVES: A number of small-scale, single-country studies have suggested that muscular weakness may be a biomarker for cognitive health, mild cognitive impairment (MCI), and dementia. However, multinational, representative studies are lacking, particularly from low- and middle-income countries (LMICs). Thus, we assessed the association between muscular strength (measured by maximal handgrip) and MCI in six LMICs (China, Ghana, India, Mexico, Russia, and South Africa), using nationally representative data. METHODS: Cross-sectional, community-based data on individuals aged 50 years or older from the World Health Organization's Study on Global Ageing and Adult Health were analyzed. MCI was defined according to the National Institute on Aging-Alzheimer's Association criteria. Weak handgrip strength was defined as less than 30 kg for men and less than 20 kg for women using the average value of two handgrip measurements of the dominant hand. Multivariable logistic regression analysis was conducted to assess the association between muscular strength and MCI. RESULTS: A total of 32 715 participants were included (mean age 62 ± SD 15.6 y and 51.7% female). The prevalence of MCI and weak handgrip strength was 15.3% (95% CI, 14.4%-16.3%) and 46.5% (95% CI, 43.6%-49.5%), respectively. After adjustment for potential confounders, weak handgrip strength was associated with 1.41 (95% CI, 1.23-1.61) times higher odds for MCI. The corresponding figures for those aged 50 to 64 years and 65 years or older were 1.35 (95% CI, 1.14-1.60) and 1.54 (95% CI, 1.27-1.86), respectively. CONCLUSIONS: Muscular weakness may provide a clinically useful indicator of MCI risk. Increasing our understanding of the connection between muscular and cognitive function could ultimately lead to the development and broader implementation of resistance training interventions targeting both physical and cognitive health.
OBJECTIVES: A number of small-scale, single-country studies have suggested that muscular weakness may be a biomarker for cognitive health, mild cognitive impairment (MCI), and dementia. However, multinational, representative studies are lacking, particularly from low- and middle-income countries (LMICs). Thus, we assessed the association between muscular strength (measured by maximal handgrip) and MCI in six LMICs (China, Ghana, India, Mexico, Russia, and South Africa), using nationally representative data. METHODS: Cross-sectional, community-based data on individuals aged 50 years or older from the World Health Organization's Study on Global Ageing and Adult Health were analyzed. MCI was defined according to the National Institute on Aging-Alzheimer's Association criteria. Weak handgrip strength was defined as less than 30 kg for men and less than 20 kg for women using the average value of two handgrip measurements of the dominant hand. Multivariable logistic regression analysis was conducted to assess the association between muscular strength and MCI. RESULTS: A total of 32 715 participants were included (mean age 62 ± SD 15.6 y and 51.7% female). The prevalence of MCI and weak handgrip strength was 15.3% (95% CI, 14.4%-16.3%) and 46.5% (95% CI, 43.6%-49.5%), respectively. After adjustment for potential confounders, weak handgrip strength was associated with 1.41 (95% CI, 1.23-1.61) times higher odds for MCI. The corresponding figures for those aged 50 to 64 years and 65 years or older were 1.35 (95% CI, 1.14-1.60) and 1.54 (95% CI, 1.27-1.86), respectively. CONCLUSIONS:Muscular weakness may provide a clinically useful indicator of MCI risk. Increasing our understanding of the connection between muscular and cognitive function could ultimately lead to the development and broader implementation of resistance training interventions targeting both physical and cognitive health.
Authors: Kristen M George; Paola Gilsanz; Rachel L Peterson; Medellena Maria Glymour; Elizabeth Rose Mayeda; Dan M Mungas; Sunita Q Miles; Rachel A Whitmer Journal: Alzheimer Dis Assoc Disord Date: 2021 Jan-Mar 01 Impact factor: 2.357
Authors: Suzanne G Orchard; Galina Polekhina; Joanne Ryan; Raj C Shah; Elsdon Storey; Trevor T-J Chong; Jessica E Lockery; Stephanie A Ward; Rory Wolfe; Mark R Nelson; Christopher M Reid; Anne M Murray; Sara E Espinoza; Anne B Newman; John J McNeil; Taya A Collyer; Michele L Callisaya; Robyn L Woods Journal: Alzheimers Dement (Amst) Date: 2022-09-22
Authors: Agnieszka Wiśniowska-Szurlej; Agnieszka Ćwirlej-Sozańska; Natalia Wołoszyn; Bernard Sozański; Anna Wilmowska-Pietruszyńska Journal: Biomed Res Int Date: 2019-09-23 Impact factor: 3.411