Ayca Ant1, Ömer Yazici2, Pinar Atabey3, Ferit Ferhat Aslan4, Arzubetul Duran3, Samet Ozlugedik3, Yusuf Kemal Kemaloglu5. 1. Department of Otorhinolaryngology, Head and Neck Surgery, University of Medical Sciences, Ankara A.Y. Oncology Education and Research Hospital, Yenimahalle, 06200, Ankara, Turkey. draycaant@gmail.com. 2. Department of Radiation Oncology, University of Medical Sciences, Ankara A.Y. Oncology Education and Research Hospital, Ankara, Turkey. 3. Department of Otorhinolaryngology, Head and Neck Surgery, University of Medical Sciences, Ankara A.Y. Oncology Education and Research Hospital, Yenimahalle, 06200, Ankara, Turkey. 4. Department of Medical Oncology, University of Medical Sciences, Ankara A.Y. Oncology Education and Research Hospital, Ankara, Turkey. 5. Department of Otorhinolaryngology, Head and Neck Surgery, Gazi University School of Medicine, Ankara, Turkey.
Abstract
PURPOSE: This study analyzed the late ear complications of radiotherapy for nasopharyngeal cancer (NPC) and compared the conventional and intensity-modulated radiotherapy (2D-RT and IMRT, respectively). METHODS: At 2-21 years after the end of NPC treatment, 104 ears of 52 patients were evaluated with the otoscopic examination, pure tone audiometry test, tympanometry, and subjective complaints by being blinded to the radiotherapy technique. RESULTS: There were no differences in terms of the pathology of the external, middle or inner ear, air and bone-conduction hearing thresholds, and the air-bone (A-B) gap at 500, 1000, 2000, and 4000 Hz, and tympanometry types between 2D-RT and IMRT groups (p > 0.05). There were positive correlations between the values of A500 and A1000 thresholds; gap 500, 4000, and mean cochlear RT dose (p < 0.05). There were positive correlations between the values of A500, A1000, and A4000 thresholds; gap 500, 1000, 2000, 4000, and maximum cochlear RT dose (p < 0.05). CONCLUSION: IMRT was not found to be superior to 2D-RT to prevent RT-induced ear complications. The solution of the middle ear problems must be the goal of the strategies for complications treatment.
PURPOSE: This study analyzed the late ear complications of radiotherapy for nasopharyngeal cancer (NPC) and compared the conventional and intensity-modulated radiotherapy (2D-RT and IMRT, respectively). METHODS: At 2-21 years after the end of NPC treatment, 104 ears of 52 patients were evaluated with the otoscopic examination, pure tone audiometry test, tympanometry, and subjective complaints by being blinded to the radiotherapy technique. RESULTS: There were no differences in terms of the pathology of the external, middle or inner ear, air and bone-conduction hearing thresholds, and the air-bone (A-B) gap at 500, 1000, 2000, and 4000 Hz, and tympanometry types between 2D-RT and IMRT groups (p > 0.05). There were positive correlations between the values of A500 and A1000 thresholds; gap 500, 4000, and mean cochlear RT dose (p < 0.05). There were positive correlations between the values of A500, A1000, and A4000 thresholds; gap 500, 1000, 2000, 4000, and maximum cochlear RT dose (p < 0.05). CONCLUSION: IMRT was not found to be superior to 2D-RT to prevent RT-induced ear complications. The solution of the middle ear problems must be the goal of the strategies for complications treatment.
Entities:
Keywords:
Cancer; Ear; Hearing; Intensity-modulated radiotherapy; Late complication; Nasopharynx; Radiotherapy
Authors: S H Chan; W T Ng; K L Kam; Michael C H Lee; C W Choi; T K Yau; Anne W M Lee; S K Chow Journal: Int J Radiat Oncol Biol Phys Date: 2008-10-14 Impact factor: 7.038
Authors: Patricia Helena Pecora Liberman; Christiane Schultz; M Valéria Schmidt Goffi Gomez; André Lopes Carvalho; Antonio Cassio Assis Pellizzon; José Ricardo Testa; Olavo Feher; Luiz Paulo Kowalski Journal: Arch Otolaryngol Head Neck Surg Date: 2004-11