J-J Li1, Y-K Guo, Q-L Tang, S-S Li, X-L Zhang, P-A Wu, X-M Yang. 1. Department of Otolaryngology, Head and Neck Surgery and the Institute of Otology, the Second Xiangya Hospital, Central South University, Hunan, People's Republic of China.
Abstract
OBJECTIVES: To investigate the severity and incidence of sensorineural hearing loss in patients with nasopharyngeal carcinoma treated with radiotherapy. METHODS: Forty-two patients with nasopharyngeal carcinoma were treated with conventional radiotherapy. Audiological testing was performed to compare patients' hearing before and at varying stages after radiotherapy. RESULTS: At one month post-radiation, a significant hearing threshold increase was seen only for high frequencies. At 12, 24 and 60 months post-radiation, significant threshold increases were observed at speech frequencies (4.0 and 8.0 kHz), compared with pre-radiation data. The mean values of wave I, III and V latencies and of the I-V interpeak latency intervals were not significantly altered at one month post-radiation, but were significantly prolonged at 12, 24 and 60 months post-radiation, compared with pre-radiation data. CONCLUSION: In patients with nasopharyngeal carcinoma treated with radiotherapy, the severity and incidence of radiation-induced sensorineural hearing loss increased with time, especially at high frequencies. This hearing impairment may be due to changes in the cochlea and/or the retrocochlear auditory pathway.
OBJECTIVES: To investigate the severity and incidence of sensorineural hearing loss in patients with nasopharyngeal carcinoma treated with radiotherapy. METHODS: Forty-two patients with nasopharyngeal carcinoma were treated with conventional radiotherapy. Audiological testing was performed to compare patients' hearing before and at varying stages after radiotherapy. RESULTS: At one month post-radiation, a significant hearing threshold increase was seen only for high frequencies. At 12, 24 and 60 months post-radiation, significant threshold increases were observed at speech frequencies (4.0 and 8.0 kHz), compared with pre-radiation data. The mean values of wave I, III and V latencies and of the I-V interpeak latency intervals were not significantly altered at one month post-radiation, but were significantly prolonged at 12, 24 and 60 months post-radiation, compared with pre-radiation data. CONCLUSION: In patients with nasopharyngeal carcinoma treated with radiotherapy, the severity and incidence of radiation-induced sensorineural hearing loss increased with time, especially at high frequencies. This hearing impairment may be due to changes in the cochlea and/or the retrocochlear auditory pathway.
Authors: Lawrance K Chung; Nolan Ung; John P Sheppard; Thien Nguyen; Carlito Lagman; Winward Choy; Stephen Tenn; Nader Pouratian; Percy Lee; Tania Kaprealian; Michael Selch; Antonio De Salles; Quinton Gopen; Isaac Yang Journal: J Neurol Surg B Skull Base Date: 2017-11-10
Authors: Eleonoor A R Theunissen; Charlotte L Zuur; Marta Lopez Yurda; Sieberen van der Baan; Anne F Kornman; Jan Paul de Boer; Alfons J M Balm; Coen R N Rasch; Wouter A Dreschler Journal: J Otolaryngol Head Neck Surg Date: 2014-08-06