Literature DB >> 3067083

Expression of MF alpha 1 in MATa cells supersensitive to alpha-factor leads to self-arrest.

M Whiteway1, L Hougan, D Y Thomas.   

Abstract

MATa cells of Saccharomyces cerevisiae defective in both the SST1 and SST2 gene products exhibit self-arrest when they express the MF alpha 1 gene under the control of the GAL1 promoter. This response to endogenously produced pheromone can be alleviated by mutations which prevent the production of, or response to, alpha-factor. Suppressors of the self-arrest phenotype include a class of mutants which remain responsive to low levels of pheromone, but are resistant to high levels of alpha-factor. One of these mutants has been mapped to chromosome X, 31 cM distal to SUP4, and defines a new locus designated STE18.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3067083     DOI： 10.1007/bf00340184

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  19 in total

Review 1.  Genetic map of Saccharomyces cerevisiae, edition 9.

Authors:  R K Mortimer; D Schild
Journal:  Microbiol Rev       Date:  1985-09

2.  Control of yeast alpha-specific genes: evidence for two blocks to expression in MATa/MAT alpha diploids.

Authors:  G Ammerer; G F Sprague; A Bender
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

3.  One-step gene disruption in yeast.

Authors:  R J Rothstein
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

4.  Control of cell type in yeast by the mating type locus. The alpha 1-alpha 2 hypothesis.

Authors:  J Strathern; J Hicks; I Herskowitz
Journal:  J Mol Biol       Date:  1981-04-15       Impact factor: 5.469

5.  The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways.

Authors:  M Whiteway; J W Szostak
Journal:  Cell       Date:  1985-12       Impact factor: 41.582

6.  The yeast repeated element sigma contains a hormone-inducible promoter.

Authors:  S W Van Arsdell; G L Stetler; J Thorner
Journal:  Mol Cell Biol       Date:  1987-02       Impact factor: 4.272

7.  Yeast cells recover from mating pheromone alpha factor-induced division arrest by desensitization in the absence of alpha factor destruction.

Authors:  S A Moore
Journal:  J Biol Chem       Date:  1984-01-25       Impact factor: 5.157

8.  Expression of the BAR1 gene in Saccharomyces cerevisiae: induction by the alpha mating pheromone of an activity associated with a secreted protein.

Authors:  T R Manney
Journal:  J Bacteriol       Date:  1983-07       Impact factor: 3.490

Review 9.  Cell interactions and regulation of cell type in the yeast Saccharomyces cerevisiae.

Authors:  G F Sprague; L C Blair; J Thorner
Journal:  Annu Rev Microbiol       Date:  1983       Impact factor: 15.500

10.  Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone.

Authors:  L H Hartwell
Journal:  J Cell Biol       Date:  1980-06       Impact factor: 10.539
View more
  10 in total

1.  The Kex2p proregion is essential for the biosynthesis of an active enzyme and requires a C-terminal basic residue for its function.

Authors:  G Lesage; A Prat; J Lacombe; D Y Thomas; N G Seidah; G Boileau
Journal:  Mol Biol Cell       Date:  2000-06       Impact factor: 4.138

2.  Overexpression of the STE4 gene leads to mating response in haploid Saccharomyces cerevisiae.

Authors:  M Whiteway; L Hougan; D Y Thomas
Journal:  Mol Cell Biol       Date:  1990-01       Impact factor: 4.272

3.  Identification and characterization of a mutation affecting the division arrest signaling of the pheromone response pathway in Saccharomyces cerevisiae.

Authors:  H Fujimura
Journal:  Genetics       Date:  1990-02       Impact factor: 4.562

4.  Yeast dynamically modify their environment to achieve better mating efficiency.

Authors:  Meng Jin; Beverly Errede; Marcelo Behar; Will Mather; Sujata Nayak; Jeff Hasty; Henrik G Dohlman; Timothy C Elston
Journal:  Sci Signal       Date:  2011-08-16       Impact factor: 8.192

5.  Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit).

Authors:  H G Dohlman; J Song; D Ma; W E Courchesne; J Thorner
Journal:  Mol Cell Biol       Date:  1996-09       Impact factor: 4.272

6.  Cloning and characterization of the SKI3 gene of Saccharomyces cerevisiae demonstrates allelism to SKI5.

Authors:  L Hougan; D Y Thomas; M Whiteway
Journal:  Curr Genet       Date:  1989-09       Impact factor: 3.886

7.  Dominant negative selection of heterologous genes: isolation of Candida albicans genes that interfere with Saccharomyces cerevisiae mating factor-induced cell cycle arrest.

Authors:  M Whiteway; D Dignard; D Y Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

8.  Interactions among the subunits of the G protein involved in Saccharomyces cerevisiae mating.

Authors:  K L Clark; D Dignard; D Y Thomas; M Whiteway
Journal:  Mol Cell Biol       Date:  1993-01       Impact factor: 4.272

9.  Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2.

Authors:  Christopher G Alvaro; Allyson F O'Donnell; Derek C Prosser; Andrew A Augustine; Aaron Goldman; Jeffrey L Brodsky; Martha S Cyert; Beverly Wendland; Jeremy Thorner
Journal:  Mol Cell Biol       Date:  2014-07       Impact factor: 4.272

10.  Isolation and characterization of S. cerevisiae mutants defective in somatostatin expression: cloning and functional role of a yeast gene encoding an aspartyl protease in precursor processing at monobasic cleavage sites.

Authors:  Y Bourbonnais; J Ash; M Daigle; D Y Thomas
Journal:  EMBO J       Date:  1993-01       Impact factor: 11.598
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.