Literature DB >> 30670634

Why geneticists stole cancer research even though cancer is primarily a signaling disease.

Michael B Yaffe1,2.   

Abstract

Genetic approaches to cancer research have dramatically advanced our understanding of the pathophysiology of this disease, leading to similar genetics-based approaches for precision therapy, which have been less successful. Reconfiguring and adapting the types of technologies that underlie genetic research to dissect tumor cell signaling in clinical samples may offer an alternative road forward.
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Year:  2019        PMID： 30670634     DOI： 10.1126/scisignal.aaw3483

Source DB:  PubMed          Journal:  Sci Signal        ISSN： 1945-0877            Impact factor:   8.192


  18 in total

Review 1.  Characterizing the ecological and evolutionary dynamics of cancer.

Authors:  Nastaran Zahir; Ruping Sun; Daniel Gallahan; Robert A Gatenby; Christina Curtis
Journal:  Nat Genet       Date:  2020-07-27       Impact factor: 38.330

2.  Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies.

Authors:  Elizabeth J Pereira; Joseph S Burns; Christina Y Lee; Taylor Marohl; Delia Calderon; Lixin Wang; Kristen A Atkins; Chun-Chao Wang; Kevin A Janes
Journal:  Sci Signal       Date:  2020-04-14       Impact factor: 8.192

3.  An in vitro model of tumor heterogeneity resolves genetic, epigenetic, and stochastic sources of cell state variability.

Authors:  Corey E Hayford; Darren R Tyson; C Jack Robbins; Peter L Frick; Vito Quaranta; Leonard A Harris
Journal:  PLoS Biol       Date:  2021-06-01       Impact factor: 8.029

Review 4.  Next-generation computational tools for interrogating cancer immunity.

Authors:  Francesca Finotello; Dietmar Rieder; Hubert Hackl; Zlatko Trajanoski
Journal:  Nat Rev Genet       Date:  2019-09-12       Impact factor: 59.581

Review 5.  Drivers of Gene Expression Dysregulation in Pancreatic Cancer.

Authors:  Swati Venkat; Abdulrahman A Alahmari; Michael E Feigin
Journal:  Trends Cancer       Date:  2021-02-19

6.  High-Density, Targeted Monitoring of Tyrosine Phosphorylation Reveals Activated Signaling Networks in Human Tumors.

Authors:  Lauren E Stopfer; Cameron T Flower; Aaron S Gajadhar; Bhavin Patel; Sebastien Gallien; Daniel Lopez-Ferrer; Forest M White
Journal:  Cancer Res       Date:  2021-01-28       Impact factor: 13.312

7.  Alternative polyadenylation drives oncogenic gene expression in pancreatic ductal adenocarcinoma.

Authors:  Swati Venkat; Arwen A Tisdale; Johann R Schwarz; Abdulrahman A Alahmari; H Carlo Maurer; Kenneth P Olive; Kevin H Eng; Michael E Feigin
Journal:  Genome Res       Date:  2020-02-06       Impact factor: 9.043

Review 8.  Recent advances in mass spectrometry based clinical proteomics: applications to cancer research.

Authors:  Andrew Macklin; Shahbaz Khan; Thomas Kislinger
Journal:  Clin Proteomics       Date:  2020-05-24       Impact factor: 3.988

9.  L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness.

Authors:  Raquel A C Machado; Dunja Stojevski; Sébastien De Landtsheer; Philippe Lucarelli; Alexandre Baron; Thomas Sauter; Elisabeth Schaffner-Reckinger
Journal:  Cell Commun Signal       Date:  2021-02-22       Impact factor: 5.712

10.  Over a century of cancer research: Inconvenient truths and promising leads.

Authors:  Carlos Sonnenschein; Ana M Soto
Journal:  PLoS Biol       Date:  2020-04-01       Impact factor: 9.593
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