Romain Bourcier1, Mayank Goyal2, David S Liebeskind3, Keith W Muir4, Hubert Desal1, Adnan H Siddiqui5, Diederik W J Dippel6, Charles B Majoie7, Wim H van Zwam8, Tudor G Jovin9, Elad I Levy5, Peter J Mitchell10, Olvert A Berkhemer7, Stephen M Davis10, Imad Derraz11, Geoffrey A Donnan12, Andrew M Demchuk2, Robert J van Oostenbrugge8, Michael Kelly13, Yvo B Roos7, Reza Jahan3, Aad van der Lugt6, Marieke Sprengers7, Stephane Velasco14, Geert J Lycklama À Nijeholt15, Wagih Ben Hassen16, Paul Burns17, Scott Brown18, Emmanuel Chabert19, Timo Krings20, Hana Choe21, Christian Weimar22, Bruce C V Campbell10, Gary A Ford23, Marc Ribo24, Phil White25, Geoffrey C Cloud26, Luis San Roman27, Antoni Davalos28, Olivier Naggara16, Michael D Hill2, Serge Bracard29. 1. Centre Hospitalier Universitaire de Nantes, Nantes Cedex, France. 2. University of Calgary, Calgary, Alberta, Canada. 3. University of California, Los Angeles Medical Center, Los Angeles. 4. University of Glasgow, Glasgow, Scotland. 5. State University of New York at Buffalo. 6. Erasmus MC, University Medical Center, Rotterdam, the Netherlands. 7. Academic Medical Center Amsterdam, Amsterdam, the Netherlands. 8. Maastricht University Medical Center, Maastricht, the Netherlands. 9. University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 10. The Royal Melbourne Hospital, Victoria, Australia. 11. University Hospital of Montpellier, Montpellier, France. 12. The Florey Institute of Neuroscience and Mental Health, Parkville, Australia. 13. Division of Neurosurgery, Department of Surgery, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. 14. University Hospital of Poitiers, Poitiers, France. 15. Department Radiology, MC Haaglanden, Leidschendam, the Netherlands. 16. Hopital Saint Anne, University Paris-Descartes, Paris, France. 17. Department of Neuroradiology, Royal Victoria Hospital, Belfast, Belfast, Ireland. 18. Altair Biostatistics, Mooresville, North Carolina. 19. Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France. 20. University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada. 21. Abington and Jefferson Health, Abington, Pennsylvania. 22. University of Duisburg-Essen, Duisburg-Essen, Germany. 23. Oxford University Hospitals National Health Services Foundation trust and University of Oxford, Oxford, England. 24. Hospital Vall d'Hebron, Barcelona, Spain. 25. Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, England. 26. Department of Clinical Neuroscience, Central Clinical School, Monash University and The Alfred Hospital, Melbourne, Australia. 27. Hospital Clinic of Barcelona, Barcelona, Spain. 28. Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain. 29. University of Lorraine, and University Hospital of Nancy, Nancy, France.
Abstract
Importance: Reperfusion is a key factor for clinical outcome in patients with acute ischemic stroke (AIS) treated with endovascular thrombectomy (EVT) for large-vessel intracranial occlusion. However, data are scarce on the association between the time from onset and reperfusion results. Objective: To analyze the rate of reperfusion after EVT started at different intervals after symptom onset in patients with AIS. Design, Setting, and Participants: We conducted a meta-analysis of individual patient data from 7 randomized trials of the Highly Effective Reperfusion Using Multiple Endovascular Devices (HERMES) group. This is a multicenter cohort study of the intervention arm of randomized clinical trials included in the HERMES group. Patients with anterior circulation AIS who underwent EVT for M1/M2 or intracranial carotid artery occlusion were included. Each trial enrolled patients according to its specific inclusion and exclusion criteria. Data on patients eligible but not enrolled (eg, refusals or exclusions) were not available. All analyses were performed by the HERMES biostatistical core laboratory using the pooled database. Data were analyzed between December 2010 and April 2015. Main Outcomes and Measures: Successful reperfusion was defined as a modified thrombolysis in cerebral infarction score of 2b/3 at the end of the EVT procedure adjusted for age, occlusion location, pretreatment intravenous thrombolysis, and clot burden score and was analyzed in relation to different intervals (onset, emergency department arrival, imaging, and puncture) using mixed-methods logistic regression. Results: Among the 728 included patients, with a mean (SD) age of 65.4 (13.5) years and of whom 345 were female (47.4%), decreases in rates of successful reperfusion defined as a thrombolysis in cerebral infarction score of 2b/3 were observed with increasing time from admission or first imaging to groin puncture. The magnitude of effect was a 22% relative reduction (odds ratio, 0.78; 95% CI, 0.64-0.95) per additional hour between admission and puncture and a 26% relative reduction (odds ratio, 0.74; 95% CI, 0.59-0.93) per additional hour between imaging and puncture. Conclusions and Relevance: Because the probability of reperfusion declined significantly with time between hospital arrival and groin puncture, we provide additional arguments for minimizing the intervals after symptom onset in anterior circulation acute ischemic stroke.
Importance: Reperfusion is a key factor for clinical outcome in patients with acute ischemic stroke (AIS) treated with endovascular thrombectomy (EVT) for large-vessel intracranial occlusion. However, data are scarce on the association between the time from onset and reperfusion results. Objective: To analyze the rate of reperfusion after EVT started at different intervals after symptom onset in patients with AIS. Design, Setting, and Participants: We conducted a meta-analysis of individual patient data from 7 randomized trials of the Highly Effective Reperfusion Using Multiple Endovascular Devices (HERMES) group. This is a multicenter cohort study of the intervention arm of randomized clinical trials included in the HERMES group. Patients with anterior circulation AIS who underwent EVT for M1/M2 or intracranial carotid artery occlusion were included. Each trial enrolled patients according to its specific inclusion and exclusion criteria. Data on patients eligible but not enrolled (eg, refusals or exclusions) were not available. All analyses were performed by the HERMES biostatistical core laboratory using the pooled database. Data were analyzed between December 2010 and April 2015. Main Outcomes and Measures: Successful reperfusion was defined as a modified thrombolysis in cerebral infarction score of 2b/3 at the end of the EVT procedure adjusted for age, occlusion location, pretreatment intravenous thrombolysis, and clot burden score and was analyzed in relation to different intervals (onset, emergency department arrival, imaging, and puncture) using mixed-methods logistic regression. Results: Among the 728 included patients, with a mean (SD) age of 65.4 (13.5) years and of whom 345 were female (47.4%), decreases in rates of successful reperfusion defined as a thrombolysis in cerebral infarction score of 2b/3 were observed with increasing time from admission or first imaging to groin puncture. The magnitude of effect was a 22% relative reduction (odds ratio, 0.78; 95% CI, 0.64-0.95) per additional hour between admission and puncture and a 26% relative reduction (odds ratio, 0.74; 95% CI, 0.59-0.93) per additional hour between imaging and puncture. Conclusions and Relevance: Because the probability of reperfusion declined significantly with time between hospital arrival and groin puncture, we provide additional arguments for minimizing the intervals after symptom onset in anterior circulation acute ischemic stroke.
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