Zhao Bi1,2, Jingjing Liu3, Peng Chen2, Yanbing Liu2, Tong Zhao2, Chunjian Wang2, Zhaopeng Zhang2, Xiao Sun2, Pengfei Qiu2, Binbin Cong1,2, Xianrang Song2, Yongsheng Wang4. 1. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, People's Republic of China. 2. Breast Cancer Center, Shandong Cancer Hospital Affiliated to Shandong University, Ji Yan Road 440, Jinan, Shandong Province, People's Republic of China. 3. Laboratory, Qingdao Municipal Hospital, Qingdao, Shandong, People's Republic of China. 4. Breast Cancer Center, Shandong Cancer Hospital Affiliated to Shandong University, Ji Yan Road 440, Jinan, Shandong Province, People's Republic of China. wangysh2008@aliyun.com.
Abstract
PURPOSE: This study aims to determine the optimal time to perform sentinel lymph node biopsy (SLNB) for patients with clinically node-negative (cN0) disease following neoadjuvant chemotherapy (NAC). METHOD: From April 2008 to April 2018, 592 patients with breast cancer underwent after NAC were included in this study. Patients with cN0 before and ycN0 disease after NAC received SLNB and axillary lymph node dissection (ALND) in case of positive sentinel lymph nodes (SLNs). For patients with clinically node-positive (cN+) disease, the axillary surgery is based on the doctor's decision. RESULT: In general, 17.6% (104/592) of patients achieved total pathologic complete response (pCR), which was 6.9%, 33.3%, 32.3% and 15.3%, respectively, among patients with hormone receptor (HR) positive/ human epidermal growth factor receptor-2 (HER-2) negative (HR+/HER2-) subtype, triple-negative (TN) subtype, HER-2 positive (HER2+) subtype with and without targeted therapy (p < 0.001). Among the 525 cN+ patients, the axillary nodal pCR (apCR) rate was 34.5%, and the apCR rate was significantly higher in patients with HER2+ (58.6% with and 28.2% without targeted therapy respectively) and TN subtype (53.2%) than that in patients with HR+/HER2-subtype (21.2%, p < 0.001). Among the 67 cN0 patients, the positive rate of SLNs was 19.4% (13/67), which was 28.1% (9/32), 13.3% (2/15) and 10.0% (2/20), respectively, among patients with HR+/HER2-, TN and HER2 + subtypes. CONCLUSION: The pCR rates were significantly related to molecular subtype. Combining the apCR rates in different molecular subtypes of cN+ patients and the excellent locoregional control of AOSOG Z0011 and AMAROS trials in cN0 patients, it would be preferable to perform SLNB prior to NAC for cN0 patients with HR+/HER2- subtype, and SLNB after NAC for those cN0 patients with TN and HER2+ subtype to increase the chance of avoiding ALND. Among cN0 patients, TN and HER2 + subtypes would benefit more from axillary de-escalating surgery after NAC than HR+/HER2- subtype.
PURPOSE: This study aims to determine the optimal time to perform sentinel lymph node biopsy (SLNB) for patients with clinically node-negative (cN0) disease following neoadjuvant chemotherapy (NAC). METHOD: From April 2008 to April 2018, 592 patients with breast cancer underwent after NAC were included in this study. Patients with cN0 before and ycN0 disease after NAC received SLNB and axillary lymph node dissection (ALND) in case of positive sentinel lymph nodes (SLNs). For patients with clinically node-positive (cN+) disease, the axillary surgery is based on the doctor's decision. RESULT: In general, 17.6% (104/592) of patients achieved total pathologic complete response (pCR), which was 6.9%, 33.3%, 32.3% and 15.3%, respectively, among patients with hormone receptor (HR) positive/ human epidermal growth factor receptor-2 (HER-2) negative (HR+/HER2-) subtype, triple-negative (TN) subtype, HER-2 positive (HER2+) subtype with and without targeted therapy (p < 0.001). Among the 525 cN+ patients, the axillary nodal pCR (apCR) rate was 34.5%, and the apCR rate was significantly higher in patients with HER2+ (58.6% with and 28.2% without targeted therapy respectively) and TN subtype (53.2%) than that in patients with HR+/HER2-subtype (21.2%, p < 0.001). Among the 67 cN0 patients, the positive rate of SLNs was 19.4% (13/67), which was 28.1% (9/32), 13.3% (2/15) and 10.0% (2/20), respectively, among patients with HR+/HER2-, TN and HER2 + subtypes. CONCLUSION: The pCR rates were significantly related to molecular subtype. Combining the apCR rates in different molecular subtypes of cN+ patients and the excellent locoregional control of AOSOG Z0011 and AMAROS trials in cN0 patients, it would be preferable to perform SLNB prior to NAC for cN0 patients with HR+/HER2- subtype, and SLNB after NAC for those cN0 patients with TN and HER2+ subtype to increase the chance of avoiding ALND. Among cN0 patients, TN and HER2 + subtypes would benefit more from axillary de-escalating surgery after NAC than HR+/HER2- subtype.
Authors: Juan C Vázquez; Antonio Piñero; Francisco J de Castro; Ana Lluch; Miguel Martín; Agustí Barnadas; Emilio Alba; Álvaro Rodríguez-Lescure; Federico Rojo; Julia Giménez; Ivan Solá; Maria J Quintana; Xavier Bonfill; Gerard Urrutia; Pedro Sánchez-Rovira Journal: Clin Transl Oncol Date: 2022-09-25 Impact factor: 3.340
Authors: Juan C Vázquez; Antonio Piñero; Francisco Javier de Castro; Ana Lluch; Miguel Martín; Agustí Barnadas; Emilio Alba; Álvaro Rodríguez-Lescure; Federico Rojo; Julia Giménez; Iván Solá; María Jesús Quintana; Xavier Bonfill; Gerard Urrutia; Pedro Sánchez-Rovira Journal: Clin Transl Oncol Date: 2022-04-12 Impact factor: 3.340
Authors: Jai Min Ryu; Hee Jun Choi; Eun Hwa Park; Ji Young Kim; Young Joo Lee; Seho Park; Jeeyeon Lee; Heung Kyu Park; Seok Jin Nam; Seok Won Kim; Jun-Hee Lee; Jeong Eon Lee Journal: J Breast Cancer Date: 2022-04 Impact factor: 2.922