Literature DB >> 30665563

TRPC6 in diabetic kidney disease: good guy or bad guy?

Alexander Staruschenko1.   

Abstract

An association of altered activity of transient receptor potential cation channel C6 (TRPC6) with the development of various diabetic complications was previously reported. In this issue, Wang et al. tested the contribution of TRPC6 in type 1 diabetes setting by breeding Akita mice with TRPC6 knockout mice. The authors revealed that the knockout of TRPC6 decreased proteinuria and attenuated tubule injury but promoted mesangial expansion in Akita mice. Therefore, TRPC6 has both beneficial and detrimental effects on glomeruli function.
Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 30665563      PMCID： PMC6800994          DOI： 10.1016/j.kint.2018.10.027

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  9 in total

1.  A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease.

Authors:  Daria V Ilatovskaya; Gregory Blass; Oleg Palygin; Vladislav Levchenko; Tengis S Pavlov; Michael N Grzybowski; Kristen Winsor; Leonid S Shuyskiy; Aron M Geurts; Allen W Cowley; Lutz Birnbaumer; Alexander Staruschenko
Journal:  J Am Soc Nephrol       Date:  2018-05-23       Impact factor: 10.121

2.  Gq signaling causes glomerular injury by activating TRPC6.

Authors:  Liming Wang; Grant Jirka; Paul B Rosenberg; Anne F Buckley; Jose A Gomez; Timothy A Fields; Michelle P Winn; Robert F Spurney
Journal:  J Clin Invest       Date:  2015-04-06       Impact factor: 14.808

3.  Protective role of Trpc6 knockout in the progression of diabetic kidney disease.

Authors:  Denisha Spires; Daria V Ilatovskaya; Vladislav Levchenko; Paula E North; Aron M Geurts; Oleg Palygin; Alexander Staruschenko
Journal:  Am J Physiol Renal Physiol       Date:  2018-06-20

4.  TRPC6 G757D Loss-of-Function Mutation Associates with FSGS.

Authors:  Marc Riehle; Anja K Büscher; Björn-Oliver Gohlke; Mario Kaßmann; Maria Kolatsi-Joannou; Jan H Bräsen; Mato Nagel; Jan U Becker; Paul Winyard; Peter F Hoyer; Robert Preissner; Dietmar Krautwurst; Maik Gollasch; Stefanie Weber; Christian Harteneck
Journal:  J Am Soc Nephrol       Date:  2016-02-18       Impact factor: 10.121

5.  Glucose specifically regulates TRPC6 expression in the podocyte in an AngII-dependent manner.

Authors:  Ramon Sonneveld; Johan van der Vlag; Marijke P A Baltissen; Sjoerd A J Verkaart; Jack F M Wetzels; Jo H M Berden; Joost G J Hoenderop; Tom Nijenhuis
Journal:  Am J Pathol       Date:  2014-04-13       Impact factor: 4.307

6.  Downregulation of TRPC6 protein expression by high glucose, a possible mechanism for the impaired Ca2+ signaling in glomerular mesangial cells in diabetes.

Authors:  Sarabeth Graham; Min Ding; Sherry Sours-Brothers; Thomas Yorio; Jian-Xing Ma; Rong Ma
Journal:  Am J Physiol Renal Physiol       Date:  2007-08-15

7.  Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice.

Authors:  Liming Wang; Jae-Hyung Chang; Anne F Buckley; Robert F Spurney
Journal:  Kidney Int       Date:  2019-02       Impact factor: 10.612

8.  Trpc6 inactivation confers protection in a model of severe nephrosis in rats.

Authors:  Eun Young Kim; Parisa Yazdizadeh Shotorbani; Stuart E Dryer
Journal:  J Mol Med (Berl)       Date:  2018-05-22       Impact factor: 4.599

9.  Podocyte injury in diabetic nephropathy: implications of angiotensin II-dependent activation of TRPC channels.

Authors:  Daria V Ilatovskaya; Vladislav Levchenko; Andrea Lowing; Leonid S Shuyskiy; Oleg Palygin; Alexander Staruschenko
Journal:  Sci Rep       Date:  2015-12-10       Impact factor: 4.379
  9 in total
  6 in total

Review 1.  Role of TRPC6 in Progression of Diabetic Kidney Disease.

Authors:  Alexander Staruschenko; Denisha Spires; Oleg Palygin
Journal:  Curr Hypertens Rep       Date:  2019-05-21       Impact factor: 5.369

2.  [Correlation between transient receptor potential canonical channel with heart and kidney injure of rat model of obstructive sleep apnea hypopnea syndrome].

Authors:  Wen Wen; Qiaoling Yao; Yulan Chen; Zhiqiang Li; Xiaojing Sun; Yu Li; Junshi Zhang; Zhulipiya Simayi; Xinjuan Xu
Journal:  Zhejiang Da Xue Xue Bao Yi Xue Ban       Date:  2020-08-25

Review 3.  Ion channels and transporters in diabetic kidney disease.

Authors:  Denisha Spires; Anna D Manis; Alexander Staruschenko
Journal:  Curr Top Membr       Date:  2019-02-18       Impact factor: 3.049

Review 4.  New insight into podocyte slit diaphragm, a therapeutic target of proteinuria.

Authors:  Hiroshi Kawachi; Yoshiyasu Fukusumi
Journal:  Clin Exp Nephrol       Date:  2020-02-04       Impact factor: 2.801

5.  Tacrolimus Protects Podocytes from Apoptosis via Downregulation of TRPC6 in Diabetic Nephropathy.

Authors:  Ruixia Ma; Ying Wang; Yan Xu; Rui Wang; Xianghua Wang; Ning Yu; Minghui Li; Yan Zhou
Journal:  J Diabetes Res       Date:  2021-05-20       Impact factor: 4.011

6.  Ethanolic Extract of Centella asiatica Treatment in the Early Stage of Hyperglycemia Condition Inhibits Glomerular Injury and Vascular Remodeling in Diabetic Rat Model.

Authors:  Wiwit A W Setyaningsih; Nur Arfian; Akbar S Fitriawan; Ratih Yuniartha; Dwi C R Sari
Journal:  Evid Based Complement Alternat Med       Date:  2021-07-06       Impact factor: 2.629
  6 in total

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