Francesca de Blasio1, Luca Scalfi2, Ada Di Gregorio2, Paola Alicante2, Andrea Bianco3, Claudio Tantucci4, Barbara Bellofiore5, Francesco de Blasio6. 1. Department of Public Health, "Federico II" University of Naples, Naples, Italy; Department of Medical Sciences, University of Turin, Turin, Italy. Electronic address: francesca.deblasio1989@gmail.com. 2. Department of Public Health, "Federico II" University of Naples, Naples, Italy. 3. Department of Translational Medical Sciences, University of Campania "L Vanvitelli," Naples, Italy. 4. Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. 5. Respiratory Medicine and Pulmonary Rehabilitation Section, Clinic Center, Private Hospital, Naples, Italy. 6. Respiratory Medicine and Pulmonary Rehabilitation Section, Clinic Center, Private Hospital, Naples, Italy; Department of Medicine and Health Sciences, "V Tiberio" University of Molise, Naples, Italy.
Abstract
BACKGROUND: Bioelectrical impedance analysis (BIA) is a valuable method for estimating fat-free mass and fat mass in patients with COPD by using specific predictive equations. In addition, raw BIA variables such as high- to low-frequency impedance ratios (IRs) and phase angle, most likely as a result of providing information on muscle quality, have been related to disease severity and mortality in patients with several diseases but never in COPD. The aim of this study was to investigate the predictive role of raw BIA variables on 2-year survival in COPD. METHODS: Impedance (Z) at 5-10-50-100-250 kHz and phase angle at 50 kHz were determined in 210 patients with COPD. Three IRs were calculated: Z at 50 kHz/Z at 5 kHz (50/5 IR), Z at 100 kHz/Z at 5 kHz (100/5 IR), and Z at 250 kHz/Z at 5 kHz (250/5 IR). Demographic, respiratory, and body composition data at baseline were recorded. All-cause mortality was assessed during 2 years of follow-up. RESULTS: After the follow-up period, all-cause mortality was 13.8%. Statistically significant differences between nonsurvivors and survivors emerged in terms of age, weight, BMI, FEV1, inspiratory capacity, and modified Medical Research Council dyspnea score. With respect to nutritional variables, nonsurvivors had lower fat-free mass (P = .031), lower fat mass (P = .015), higher IRs (P < .001 for all the ratios), and lower phase angle (P < .001) compared with survivors. After adjustment for confounding factors, each unit increase of IRs and each unit decrease of phase angle were associated with a higher risk of death. CONCLUSIONS: IRs and phase angle, as raw BIA variables, are independent and powerful predictors of all-cause mortality in COPD and should be considered, together with inspiratory capacity and 6-min walk distance, as significant prognostic factors in the short- to middle-term.
BACKGROUND: Bioelectrical impedance analysis (BIA) is a valuable method for estimating fat-free mass and fat mass in patients with COPD by using specific predictive equations. In addition, raw BIA variables such as high- to low-frequency impedance ratios (IRs) and phase angle, most likely as a result of providing information on muscle quality, have been related to disease severity and mortality in patients with several diseases but never in COPD. The aim of this study was to investigate the predictive role of raw BIA variables on 2-year survival in COPD. METHODS: Impedance (Z) at 5-10-50-100-250 kHz and phase angle at 50 kHz were determined in 210 patients with COPD. Three IRs were calculated: Z at 50 kHz/Z at 5 kHz (50/5 IR), Z at 100 kHz/Z at 5 kHz (100/5 IR), and Z at 250 kHz/Z at 5 kHz (250/5 IR). Demographic, respiratory, and body composition data at baseline were recorded. All-cause mortality was assessed during 2 years of follow-up. RESULTS: After the follow-up period, all-cause mortality was 13.8%. Statistically significant differences between nonsurvivors and survivors emerged in terms of age, weight, BMI, FEV1, inspiratory capacity, and modified Medical Research Council dyspnea score. With respect to nutritional variables, nonsurvivors had lower fat-free mass (P = .031), lower fat mass (P = .015), higher IRs (P < .001 for all the ratios), and lower phase angle (P < .001) compared with survivors. After adjustment for confounding factors, each unit increase of IRs and each unit decrease of phase angle were associated with a higher risk of death. CONCLUSIONS: IRs and phase angle, as raw BIA variables, are independent and powerful predictors of all-cause mortality in COPD and should be considered, together with inspiratory capacity and 6-min walk distance, as significant prognostic factors in the short- to middle-term.
Authors: Stefanie E Mason; Rafael Moreta-Martinez; Wassim W Labaki; Matthew J Strand; Elizabeth A Regan; Jessica Bon; Ruben San Jose Estepar; Richard Casaburi; Merry-Lynn McDonald; Harry B Rossiter; Barry Make; Mark T Dransfield; MeiLan K Han; Kendra Young; Jeffrey L Curtis; Kathleen Stringer; Greg Kinney; John E Hokanson; Raul San Jose Estepar; George R Washko Journal: Chest Date: 2021-11-14 Impact factor: 10.262
Authors: Giada Ballarin; Luca Scalfi; Fabiana Monfrecola; Paola Alicante; Alessandro Bianco; Maurizio Marra; Anna Maria Sacco Journal: Int J Environ Res Public Health Date: 2021-11-30 Impact factor: 3.390
Authors: Felipe V C Machado; Ada E M Bloem; Tessa Schneeberger; Inga Jarosch; Rainer Gloeckl; Sandra Winterkamp; Frits M E Franssen; Andreas R Koczulla; Fabio Pitta; Martijn A Spruit; Klaus Kenn Journal: BMJ Open Respir Res Date: 2021-10
Authors: Paola N Cruz Rivera; Rebekah L Goldstein; Madeline Polak; Antonio A Lazzari; Marilyn L Moy; Emily S Wan Journal: Sci Rep Date: 2022-02-04 Impact factor: 4.996