Akinori Higaki1, Antoine Caillon1, Pierre Paradis1, Ernesto L Schiffrin2,3. 1. Lady Davis Institute for Medical Research, 3755 Côte-Ste-Catherine Rd, Montreal, Quebec, H3T 1E2, Canada. 2. Lady Davis Institute for Medical Research, 3755 Côte-Ste-Catherine Rd, Montreal, Quebec, H3T 1E2, Canada. ernesto.schiffrin@mcgill.ca. 3. Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, 3755 Côte-Ste-Catherine Rd, Montreal, Quebec, H3T 1E2, Canada. ernesto.schiffrin@mcgill.ca.
Abstract
PURPOSE OF REVIEW: To describe the important role played by innate and innate-like immunity in the pathophysiology of hypertension and vascular injury. RECENT FINDINGS: Innate immune cells, such as neutrophils, dendritic cells, myeloid-derived suppressor cells, and monocytes/macrophages and innate lymphoid cells such as natural killer cells and unconventional T lymphocytes like γδ T cells contribute to hypertensive mechanisms by priming adaptive immune cells, leading to the triggering of vascular inflammation and blood pressure elevation or alternatively protecting against vascular injury. Specifically, monocyte/macrophages and γδ T cells seem to play a crucial role in the initiation of hypertension via regulation of adaptive immunity. Innate and innate-like immunity play a leading role in the pathophysiology of hypertension. Recent advances in this field provide us clues for future therapeutic approaches.
PURPOSE OF REVIEW: To describe the important role played by innate and innate-like immunity in the pathophysiology of hypertension and vascular injury. RECENT FINDINGS: Innate immune cells, such as neutrophils, dendritic cells, myeloid-derived suppressor cells, and monocytes/macrophages and innate lymphoid cells such as natural killer cells and unconventional T lymphocytes like γδ T cells contribute to hypertensive mechanisms by priming adaptive immune cells, leading to the triggering of vascular inflammation and blood pressure elevation or alternatively protecting against vascular injury. Specifically, monocyte/macrophages and γδ T cells seem to play a crucial role in the initiation of hypertension via regulation of adaptive immunity. Innate and innate-like immunity play a leading role in the pathophysiology of hypertension. Recent advances in this field provide us clues for future therapeutic approaches.
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