Juan J Tarín1,2, Eva Pascual3, Miguel-Ángel García-Pérez4,5, Raúl Gómez4, Antonio Cano6,7. 1. Department of Cellular Biology, Functional Biology and Physical Anthropology, Faculty of Biological Sciences, University of Valencia, Dr. Moliner 50, 46100, Burjassot, Valencia, Spain. tarinjj@uv.es. 2. Institute of Health Research INCLIVA, Valencia, Spain. tarinjj@uv.es. 3. Department of Cellular Biology, Functional Biology and Physical Anthropology, Faculty of Biological Sciences, University of Valencia, Dr. Moliner 50, 46100, Burjassot, Valencia, Spain. 4. Institute of Health Research INCLIVA, Valencia, Spain. 5. Department of Genetics, Faculty of Biological Sciences, University of Valencia, Burjassot, Valencia, Spain. 6. Department of Pediatrics, Obstetrics and Gynecology, Faculty of Medicine, University of Valencia, Valencia, Spain. 7. Service of Obstetrics and Gynecology, University Clinic Hospital, Valencia, Spain.
Abstract
PURPOSE: The present study aims to ascertain whether there is a causal relationship between women's disease conditions present at the starting time of the first intended oocyte retrieval cycle and IVF/ICSI outcomes, primarily odds of live birth in the first IVF/ICSI treatment. METHODS: This is a retrospective study of infertile healthy and diseased women that had a live birth and/or exhibited a complete first oocyte retrieval cycle. Generalized Estimating Equations (GEE) models were applied to adjust standard errors for the potential correlation among women exhibiting the same infertility etiology. Confounders to be controlled for in these GEE models were previously selected following a strict stepwise methodology. RESULTS: Compared to healthy women, diseased women exhibited lower odds of live birth (OR (95% CI) 0.704 (0.576-0.860)). Further screening analyses indicated that subclinical iodine-deficiency hypothyroidism together with autoimmune thyroiditis contributed significantly to decrease odds of live birth (OR (95% CI) 0.720 (0.608-0.853)). Another important contribution arose from practically all the remaining morbid conditions analyzed. These diseases were individually associated with lower odds of live birth, although differences were non-significant. Notwithstanding, differences became significant after merging these diseases in a single group (OR (95% CI) 0.605 (0.394-0.930)). CONCLUSION: There is a significant causal association between most diseases present at the starting time of the first intended oocyte retrieval cycle and lower odds of live birth in the first IVF/ICSI treatment.
PURPOSE: The present study aims to ascertain whether there is a causal relationship between women's disease conditions present at the starting time of the first intended oocyte retrieval cycle and IVF/ICSI outcomes, primarily odds of live birth in the first IVF/ICSI treatment. METHODS: This is a retrospective study of infertile healthy and diseased women that had a live birth and/or exhibited a complete first oocyte retrieval cycle. Generalized Estimating Equations (GEE) models were applied to adjust standard errors for the potential correlation among women exhibiting the same infertility etiology. Confounders to be controlled for in these GEE models were previously selected following a strict stepwise methodology. RESULTS: Compared to healthy women, diseased women exhibited lower odds of live birth (OR (95% CI) 0.704 (0.576-0.860)). Further screening analyses indicated that subclinical iodine-deficiency hypothyroidism together with autoimmune thyroiditis contributed significantly to decrease odds of live birth (OR (95% CI) 0.720 (0.608-0.853)). Another important contribution arose from practically all the remaining morbid conditions analyzed. These diseases were individually associated with lower odds of live birth, although differences were non-significant. Notwithstanding, differences became significant after merging these diseases in a single group (OR (95% CI) 0.605 (0.394-0.930)). CONCLUSION: There is a significant causal association between most diseases present at the starting time of the first intended oocyte retrieval cycle and lower odds of live birth in the first IVF/ICSI treatment.
Entities:
Keywords:
Cumulative live birth; Disease conditions; In vitro fertilization; Infertility etiology; Morbid conditions
Authors: Juan J Tarín; Eva Pascual; Santiago Pérez-Hoyos; Raúl Gómez; Miguel A García-Pérez; Antonio Cano Journal: J Assist Reprod Genet Date: 2019-12-05 Impact factor: 3.412
Authors: Juan J Tarín; Eva Pascual; Miguel A García-Pérez; Raúl Gómez; Juan J Hidalgo-Mora; Antonio Cano Journal: J Assist Reprod Genet Date: 2019-12-03 Impact factor: 3.412