Hui He1, Shuang Jing1, Fei Gong2, Yue Qiu Tan2, Guang Xiu Lu2, Ge Lin3. 1. Institute of Reproductive & Stem Cell Engineering, Central South University, Changsha, China; Key Laboratory of Reproductive & Stem Cell Engineering, Ministry of Health, Changsha, China. 2. Institute of Reproductive & Stem Cell Engineering, Central South University, Changsha, China; Key Laboratory of Reproductive & Stem Cell Engineering, Ministry of Health, Changsha, China; Reproductive Center, Reproductive & Genetic Hospital of CITIC-Xiangya, Changsha 410078, China. 3. Institute of Reproductive & Stem Cell Engineering, Central South University, Changsha, China; Key Laboratory of Reproductive & Stem Cell Engineering, Ministry of Health, Changsha, China; Reproductive Center, Reproductive & Genetic Hospital of CITIC-Xiangya, Changsha 410078, China. Electronic address: linggf@hotmail.com.
Abstract
OBJECTIVE: Thyroid autoimmunity (TA) is the most prevalent autoimmune disease in women of reproductive age and is often accompanied by subclinical hypothyroidism (SCH). Both TA and SCH have been associated with adverse pregnancy outcomes, but their relative influence is unclear. Therefore, we carried out a meta-analysis to evaluate the sole effect of TA on pregnancy outcomes in euthyroid women undergoing assisted reproductive technology. MATERIALS AND METHODS: Literature searches were conducted on Pubmed, EMBASE, and the Cochrane Controlled Trials Register Database from inception to May 2014. RESULTS: In euthyroid women whose SCH status is unknown, those with positive antithyroid antibodies (ATA) had a higher miscarriage rate [pooled relative risk (RR) = 1.638; 95% confidence interval (CI), 1.228-2.185] and a lower delivery rate (pooled RR = 0.856; 95% CI, 0.759-0.965) than those with negative ATA. Clinical pregnancy rates were similar between groups. However, clinical pregnancy rate, miscarriage rate, and delivery rate were all comparable between ATA-positive and ATA-negative euthyroid women without SCH. CONCLUSION: TA per se does not impair assisted reproductive treatment outcomes in women without SCH.
OBJECTIVE:Thyroid autoimmunity (TA) is the most prevalent autoimmune disease in women of reproductive age and is often accompanied by subclinical hypothyroidism (SCH). Both TA and SCH have been associated with adverse pregnancy outcomes, but their relative influence is unclear. Therefore, we carried out a meta-analysis to evaluate the sole effect of TA on pregnancy outcomes in euthyroid women undergoing assisted reproductive technology. MATERIALS AND METHODS: Literature searches were conducted on Pubmed, EMBASE, and the Cochrane Controlled Trials Register Database from inception to May 2014. RESULTS: In euthyroid women whose SCH status is unknown, those with positive antithyroid antibodies (ATA) had a higher miscarriage rate [pooled relative risk (RR) = 1.638; 95% confidence interval (CI), 1.228-2.185] and a lower delivery rate (pooled RR = 0.856; 95% CI, 0.759-0.965) than those with negative ATA. Clinical pregnancy rates were similar between groups. However, clinical pregnancy rate, miscarriage rate, and delivery rate were all comparable between ATA-positive and ATA-negative euthyroid women without SCH. CONCLUSION: TA per se does not impair assisted reproductive treatment outcomes in women without SCH.
Authors: S La Vignera; G Defeudis; R Mazzilli; S Medenica; A M Di Tommaso; G Fabozzi; V Zamponi; D Cimadomo; L Rienzi; F M Ubaldi; M Watanabe; A Faggiano Journal: J Endocrinol Invest Date: 2022-08-09 Impact factor: 5.467
Authors: C C Repelaer van Driel-Delprat; E W C M van Dam; P M van de Ven; S Homsma; L van der Kooij; E Vis; R P Peeters; R Schats; C B Lambalk Journal: Hum Reprod Open Date: 2019-02-23