| Literature DB >> 30650338 |
E Acquarone1, F Monacelli2, R Borghi1, A Nencioni1, P Odetti1.
Abstract
From a biological point of view, aging can be considered a progressive inability of an organism to react to stress, maintain homeostasis, and survive unfavourable changes during post-maturational life. The expression of several adipokines changes during aging and for some changes, a role in the onset of chronic disease and frailty has been proposed. Among adipokines, resistin was shown in recent studies to play a key role in aging. Resistin is a small secreted protein that regulates glucose metabolism in mammalians. High resistin levels induce insulin resistance and exert proinflammatory effects. Consistently, resistin has been shown to play a pivotal role in various metabolic, inflammatory, and autoimmune diseases. Herein, the role of resistin as a molecular link between aging and age-related conditions was reviewed and the clinical implications of this knowledge discussed.Entities:
Keywords: Adipokines; Aging; Alzheimer’s disease; Metabolism; Resistin
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Year: 2019 PMID： 30650338 DOI： 10.1016/j.mad.2019.01.004
Source DB: PubMed Journal: Mech Ageing Dev ISSN： 0047-6374 Impact factor: 5.432