Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference.

Literature DB >> 30649660

Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference.

Jarek Wosik^1,2, Martha Suarez-Villagran^3,4, John H Miller^3,4, Rafik M Ghobrial^5,6, Malgorzata Kloc^7,8,9.

Abstract

In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe how mechanical/magnetic, genetic, or pharmacologic interference with the actin cytoskeleton enforces changes in cell shape and function and how such techniques can be used to control the phenotype and functions of immune cells such as macrophages and to develop novel anti-cancer and anti-rejection clinical therapies.

Entities: Disease Gene

Keywords: Actin; Cancer; Macrophage; Magnetic field; RhoA; Transplantation

Mesh：

Substances：
rhoA GTP-Binding Protein

Year: 2019 PMID： 30649660 DOI： 10.1007/s12026-019-9066-3

Source DB: PubMed Journal: Immunol Res ISSN： 0257-277X Impact factor: 2.829

52 in total

Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference.

1. ROCK inhibition impedes macrophage polarity and functions.

2. Modulation of macrophage phenotype by cell shape.

Review 3. Mitochondrial control of immunity: beyond ATP.

Review 4. Physically based principles of cell adhesion mechanosensitivity in tissues.

5. Acute and chronic rejection: compartmentalization and kinetics of counterbalancing signals in cardiac transplants.

Review 6. Captivating New Roles of F-Actin Cortex in Exocytosis and Bulk Endocytosis in Neurosecretory Cells.

7. Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks.

8. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors.

9. A role for actin, Cdc1p, and Myo2p in the inheritance of late Golgi elements in Saccharomyces cerevisiae.

10. Endosomes derived from clathrin-independent endocytosis serve as precursors for endothelial lumen formation.

1. Titania nanospikes activate macrophage phagocytosis by ligand-independent contact stimulation.

2. Promotion on NLRC5 upregulating MHC-I expression by IFN-γ in MHC-I-deficient breast cancer cells.

3. The Effect of Magnetic Field Gradient and Gadolinium-Based MRI Contrast Agent Dotarem on Mouse Macrophages.

Review 4. Innate Immune Regulation Under Magnetic Fields With Possible Mechanisms and Therapeutic Applications.