Leonardo De Luca1, Pier Luigi Temporelli2, Carmine Riccio3, Lucio Gonzini4, Lina Marinacci5, Sara Norma Tartaglione6, Paolo Costa7, Marino Scherillo8, Michele Senni9, Furio Colivicchi10, Michele Massimo Gulizia11. 1. Division of Cardiology, Interventional Cardiology Unit, S. Giovanni Evangelista Hospital, Via Parrozzani, 3 Tivoli, Rome, Italy. 2. Division of Cardiology, Istituti Clinici Scientifici Maugeri, IRCCS, Veruno, Via Revislate, 13, Novara, Italy. 3. Division of Cardiology, Azienda Ospedaliera Sant'Anna e San Sebastiano, Via F. Palasciano, Caserta, Italy. 4. ANMCO Research Center, Via A. la Marmora, 36, Firenze, Italy. 5. Division of Cardiology, Presidio Ospedaliero Città di Castello, Via L. Angelini, 10, Perugia, Italy. 6. Division of Cardiology, Presidio Ospedaliero of Sanremo, Via Giovanni Borea, 56, Imperia, Italy. 7. Division of Cardiology, G Di Maria Hospital, Avola, Vi G Mazzini, Siracusa, Italy. 8. Division of Cardiology, Azienda Ospedaliera G. Rummo, Via Pacevecchia, 53, Benevento, Italy. 9. Division of Cardiology, ASST Papa Giovanni XXIII, Piazza OMS, 1, Bergamo, Italy. 10. Division of Cardiology, S. Filippo Neri Hospital, Via Giovanni Martinotti, 20, Rome, Italy. 11. Division of Cardiology, Garibaldi-Nesima Hospital, Via Palermo, 636, Catania, Italy.
Abstract
AIMS: We evaluated the 1-year clinical events, pharmacological management, and quality of life in a contemporary cohort of stable coronary artery disease (CAD) patients managed by cardiologists. METHODS AND RESULTS: START (STable Coronary Artery Diseases RegisTry) was a prospective, observational, nationwide study that enrolled 5070 stable CAD patients over 3 months in 183 cardiology centres in Italy. At 1 year, 4790 (94.5%) patients had data on vital status. Death occurred in 107 (2.2%) patients and the cause of death was cardiovascular in 41 (38.3%) of cases. Among the 4775 patients with follow-up data on clinical events available, a hospitalization due to cardiovascular and non-cardiovascular causes occurred in 523 (11.0%) and in 231 (4.8%) of cases, respectively. Over 60% of patients reported as 'no problems' in all domains (61.4-84.5%) of the EuroQoL quality of life 5D-5L questionnaire. Among the 3239 patients with clinical visit/telephone interview at follow-up, in whom optimal medical therapy (OMT; aspirin or thienopyridine, β-blocker, and statin) was prescribed at enrolment, 2971 (91.7%) were still receiving OMT at follow-up. At multivariable analysis, only increasing age (odds ratio 0.98; 95% confidence interval 0.97-0.99; P = 0.04) resulted as independent negative predictor of OMT persistence at 1 year from enrolment. CONCLUSION: In this large, contemporary registry, stable CAD patients managed by cardiologists presented a high rate of clinical events at 1 year. Nevertheless, the persistence to OMT and quality of life appeared reasonable. Published on behalf of the European Society of Cardiology. All rights reserved.
AIMS: We evaluated the 1-year clinical events, pharmacological management, and quality of life in a contemporary cohort of stable coronary artery disease (CAD) patients managed by cardiologists. METHODS AND RESULTS: START (STable Coronary Artery Diseases RegisTry) was a prospective, observational, nationwide study that enrolled 5070 stable CAD patients over 3 months in 183 cardiology centres in Italy. At 1 year, 4790 (94.5%) patients had data on vital status. Death occurred in 107 (2.2%) patients and the cause of death was cardiovascular in 41 (38.3%) of cases. Among the 4775 patients with follow-up data on clinical events available, a hospitalization due to cardiovascular and non-cardiovascular causes occurred in 523 (11.0%) and in 231 (4.8%) of cases, respectively. Over 60% of patients reported as 'no problems' in all domains (61.4-84.5%) of the EuroQoL quality of life 5D-5L questionnaire. Among the 3239 patients with clinical visit/telephone interview at follow-up, in whom optimal medical therapy (OMT; aspirin or thienopyridine, β-blocker, and statin) was prescribed at enrolment, 2971 (91.7%) were still receiving OMT at follow-up. At multivariable analysis, only increasing age (odds ratio 0.98; 95% confidence interval 0.97-0.99; P = 0.04) resulted as independent negative predictor of OMT persistence at 1 year from enrolment. CONCLUSION: In this large, contemporary registry, stable CAD patients managed by cardiologists presented a high rate of clinical events at 1 year. Nevertheless, the persistence to OMT and quality of life appeared reasonable. Published on behalf of the European Society of Cardiology. All rights reserved.
Authors: Remo H M Furtado; Robert P Giugliano; Talia F Dalcoquio; Flavia B B Arantes; Carlos J D G Barbosa; Paulo R R Genestreti; André Franci; Fernando R Menezes; Carlos A K Nakashima; Marco A Scanavini Filho; Aline G Ferrari; Rocio Salsoso; Luciano M Baracioli; Jose C Nicolau Journal: J Thromb Thrombolysis Date: 2019-08 Impact factor: 2.300
Authors: Marco Valgimigli; Felice Gragnano; Mattia Branca; Anna Franzone; Usman Baber; Yangsoo Jang; Takeshi Kimura; Joo-Yong Hahn; Qiang Zhao; Stephan Windecker; Charles M Gibson; Byeong-Keuk Kim; Hirotoshi Watanabe; Young Bin Song; Yunpeng Zhu; Pascal Vranckx; Shamir Mehta; Sung-Jin Hong; Kenji Ando; Hyeon-Cheol Gwon; Patrick W Serruys; George D Dangas; Eùgene P McFadden; Dominick J Angiolillo; Dik Heg; Peter Jüni; Roxana Mehran Journal: BMJ Date: 2021-06-16