Literature DB >> 30648836

Psoriasis and the TNF/IL23/IL17 axis.

Kazuhisa Furue1, Takamichi Ito1, Gaku Tsuji1, Takafumi Kadono2, Masutaka Furue3.   

Abstract

The excellent response of psoriasis to anti-TNF-α(TNF)/IL23/IL17A biologics implies a crucial role for the TNF/IL23/IL17 axis in developing psoriasis. In addition to the TNF/IL23/IL17 axis provided by immune cells, current evidence points to an important contribution of TNF, IL23 and IL17C produced from non-hematopoietic keratinocytes. Therefore, crosstalk between immune cells and keratinocytes forms a multilayered feed-forward loop to accelerate the TNF/IL23/IL17A axis. Many biologics have already been licensed or are under clinical trials. Given that the IL-17 signature is more upregulated in the skin than in synovium in psoriatic arthritis, anti-IL-23/IL-17 agents seem to be superior to anti-TNF-α remedies in the treatment of skin lesions. In this review, we summarize recent topics in psoriasis and the TNF/IL23/IL17 axis.

Entities:  

Year:  2019        PMID： 30648836     DOI： 10.23736/S0392-0488.18.06202-8

Source DB:  PubMed          Journal:  G Ital Dermatol Venereol        ISSN： 0392-0488            Impact factor:   2.011


  21 in total

1.  Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis.

Authors:  Gaku Tsuji; Akiko Hashimoto-Hachiya; Vu Hai Yen; Masaki Takemura; Ayako Yumine; Kazuhisa Furue; Masutaka Furue; Takeshi Nakahara
Journal:  Cell Death Discov       Date:  2020-03-04

2.  Two cases of Erythrodermic psoriasis treated with Golimumab.

Authors:  Mayssoun Kudsi; Mhd Amin Alzabibi; Mosa Shibani
Journal:  Ann Med Surg (Lond)       Date:  2022-06-08

3.  Cytokine induced 3-D organotypic psoriasis skin model demonstrates distinct roles for NF-κB and JAK pathways in disease pathophysiology.

Authors:  Viktor Todorović; Heath A McDonald; Paul Hoover; Joseph B Wetter; Anastasia E Marinopoulos; Clarissa L Woody; Loan Miller; Ariel Finkielsztein; Robert W Dunstan; Amy S Paller; Prisca Honore; Spiro Getsios; Victoria E Scott
Journal:  Exp Dermatol       Date:  2022-03-07       Impact factor: 4.511

4.  Transcriptome Analysis Reveals Intrinsic Proinflammatory Signaling in Healthy African American Skin.

Authors:  Anna Klopot; Gleb Baida; Alexander Kel; Lam C Tsoi; Bethany E Perez White; Irina Budunova
Journal:  J Invest Dermatol       Date:  2021-10-29       Impact factor: 7.590

Review 5.  Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis.

Authors:  Masutaka Furue; Akiko Hashimoto-Hachiya; Gaku Tsuji
Journal:  Int J Mol Sci       Date:  2019-10-31       Impact factor: 5.923

6.  The EGFR-ERK/JNK-CCL20 Pathway in Scratched Keratinocytes May Underpin Koebnerization in Psoriasis Patients.

Authors:  Kazuhisa Furue; Takamichi Ito; Yuka Tanaka; Akiko Hashimoto-Hachiya; Masaki Takemura; Maho Murata; Makiko Kido-Nakahara; Gaku Tsuji; Takeshi Nakahara; Masutaka Furue
Journal:  Int J Mol Sci       Date:  2020-01-09       Impact factor: 5.923

7.  Network Pharmacology-Based Analysis on the Mechanism of Action of Ephedrae Herba-Cinnamomi Ramulus Couplet Medicines in the Treatment for Psoriasis.

Authors:  Shun Guo; Jin-Yong Zhou; Cheng Tan; Le Shi; Yue Shi; Jianxin Shi
Journal:  Med Sci Monit       Date:  2021-01-29

Review 8.  Regulating the Polarization of Macrophages: A Promising Approach to Vascular Dermatosis.

Authors:  Huiling Peng; Dehai Xian; Jiexiong Liu; Shihong Pan; Ran Tang; Jianqiao Zhong
Journal:  J Immunol Res       Date:  2020-07-28       Impact factor: 4.818

Review 9.  Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis.

Authors:  Masutaka Furue
Journal:  Int J Mol Sci       Date:  2020-07-29       Impact factor: 5.923

10.  Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis.

Authors:  Gaku Tsuji; Akiko Hashimoto-Hachiya; Vu Hai Yen; Masaki Takemura; Ayako Yumine; Kazuhisa Furue; Masutaka Furue; Takeshi Nakahara
Journal:  Cell Death Discov       Date:  2020-03-04
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