Literature DB >> 30647449

A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis.

E R Hawken1, C P Normandeau1, J Gardner Gregory1, B Cécyre2, J-F Bouchard2, K Mackie3, É C Dumont4.   

Abstract

Nestled within feeding circuits, the oval (ov) region of the Bed Nucleus of the Stria Terminalis (BNST) may be critical for monitoring energy balance through changes in synaptic strength. Here we report that bidirectional plasticity at ovBNST GABA synapses was tightly linked to the caloric state of male rats, seesawing between long-term potentiation (iLTP, fed) and depression (iLTD, food restricted). L-α-lysophosphatidylinositol (LPI) acting on GPR55 receptors and 2-arachidonoylglycerol (2-AG) through CB1R were respectively responsible for fed (iLTP) and food restricted (iLTD) states. Thus, we have characterized a potential gating mechanism within the ovBNST that may signal metabolic state within the rat brain feeding circuitry.

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Year:  2019        PMID： 30647449      PMCID： PMC6785105          DOI： 10.1038/s41386-018-0309-0

Source DB:  PubMed          Journal:  Neuropsychopharmacology        ISSN： 0893-133X            Impact factor:   7.853


  61 in total

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