BACKGROUND: The liver is the most common site for metastases of several primary malignancies including uveal melanoma. METHODS: Review of imaging characteristics of incidental common benign liver lesions including hepatic cyst, hemangioma, focal nodular hyperplasia, and hepatic adenoma and contrasting them with uveal melanoma metastases. RESULTS: Benign hepatic lesions may be cystic or, if solid, relatively stable in size over time. For hepatic lesions larger than 10 mm in size, characteristic imaging features typically allow for confident diagnosis. When lesions are small (less than 10 mm), definitive characterization can be difficult. Moreover, lesions smaller than 10 mm can be difficult to biopsy under ultrasound or computed tomography (CT) guidance, and short-term follow-up will often be useful to assess for stability or progression. Overall, magnetic resonance imaging is more specific than CT scan and at least as sensitive as CT for detecting uveal melanoma liver metastases. CONCLUSIONS: New multiple enhancing solid liver lesions should raise suspicion of uveal melanoma liver metastases. Discussion of challenging cases with the radiologist may be beneficial, as pertinent information such as size, location, and molecular prognostication status of the primary tumor can guide radiological interpretation of hepatic lesions.
BACKGROUND: The liver is the most common site for metastases of several primary malignancies including uveal melanoma. METHODS: Review of imaging characteristics of incidental common benign liver lesions including hepatic cyst, hemangioma, focal nodular hyperplasia, and hepatic adenoma and contrasting them with uveal melanoma metastases. RESULTS: Benign hepatic lesions may be cystic or, if solid, relatively stable in size over time. For hepatic lesions larger than 10 mm in size, characteristic imaging features typically allow for confident diagnosis. When lesions are small (less than 10 mm), definitive characterization can be difficult. Moreover, lesions smaller than 10 mm can be difficult to biopsy under ultrasound or computed tomography (CT) guidance, and short-term follow-up will often be useful to assess for stability or progression. Overall, magnetic resonance imaging is more specific than CT scan and at least as sensitive as CT for detecting uveal melanoma liver metastases. CONCLUSIONS: New multiple enhancing solid liver lesions should raise suspicion of uveal melanoma liver metastases. Discussion of challenging cases with the radiologist may be beneficial, as pertinent information such as size, location, and molecular prognostication status of the primary tumor can guide radiological interpretation of hepatic lesions.
Authors: Marie Diener-West; Sandra M Reynolds; Donna J Agugliaro; Robert Caldwell; Kristi Cumming; John D Earle; Barbara S Hawkins; James A Hayman; Ishmael Jaiyesimi; Lee M Jampol; John M Kirkwood; Wui-Jin Koh; Dennis M Robertson; John M Shaw; Bradley R Straatsma; Jonni Thoma Journal: Arch Ophthalmol Date: 2005-12
Authors: Marie Diener-West; Sandra M Reynolds; Donna J Agugliaro; Robert Caldwell; Kristi Cumming; John D Earle; Donna L Green; Barbara S Hawkins; James Hayman; Ishmael Jaiyesimi; John M Kirkwood; Wui-Jin Koh; Dennis M Robertson; John M Shaw; Jonni Thoma Journal: J Clin Oncol Date: 2004-06-15 Impact factor: 44.544
Authors: Antonio Piñeiro Ces; Manuel Bande Rodriguez; Javier Mosquero Sueiro; Ana María Carballo Castro; Ramón Lobato Busto; Paula Silva Rodriguez; María Pardo Pérez; Francisco Ruiz Oliva-Ruiz; Maria Jose Blanco Teijeiro Journal: J Contemp Brachytherapy Date: 2021-04-14
Authors: Amy C Schefler; Alison Skalet; Scott Cn Oliver; John Mason; Anthony B Daniels; Katherina M Alsina; Kristen M Plasseraud; Federico A Monzon; Brian Firestone Journal: Melanoma Manag Date: 2020-03-11