Morteza Izadi1, Ramin Kheirjou2, Roya Mohammadpour3, Mohammad Hassan Aliyoldashi3, Saeedreza Jamali Moghadam4, Farzin Khorvash5, Nematollah Jonaidi Jafari6, Shahram Shirvani7, Nahid Khalili6. 1. Ozone Therapy Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. 2. Ozone Therapy Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: dk_ramin@yahoo.com. 3. Department of Physiology, Faculty of Veterinary Medicine, University of Tabriz, Iran. 4. Ziaeian Hospital, Teheran University of Medical Sciences, Teheran, Iran. 5. Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 6. Health Research Center, Baitullah University of Medical Sciences, Tehran, Iran. 7. Microbiology Research Center, Baqiyatallah University Medical of Sciences, Tehran, Iran.
Abstract
BACKGROUND: Diabetic foot ulcer is one of the common complications of diabetes disease that is costly and difficult to treat. This problem can lead to morbidity and even mortality. Ozone is a gas that can optimize cellular metabolism and, because of its antioxidant and antibacterial effects, can help the better healing of diabetic foot ulcer. METHOD:Two hundred patients, aged 18-85 with diabetic foot ulcers ranging from grade 1 to 4 according to Wagner classification in two groups were studied. Group 1 was treated by full ozone therapy besides the standard regular DFU treatment while group two just was received routine diabetic foot care. Wound size, wound grade, healing time, Fasting blood sugar and inflammatory biomarker before and after treatment were checked. RESULTS: All patients have had complete wound closure in the ozone group. The mean age of the patients included in the results was 59.03 ± 12.593 and 53.5 ± 10.212 for ozone group and control group. The baseline average surface area of ulcers was 13.41 ± 14.092 cm2 (range 1-70 cm2) in ozone group and 12.72 ± 0.911 (range 1_64 cm2) in the control group. Average healing time was 69.44 ± 36.055 days (range 15-180 days), which is significantly lower than the median healing time measured in the control group and some previous studies. CONCLUSION: Our study results support the efficacy of ozone therapy especially in its comprehensive use in DFU healing and reduction in the chances of infection and amputation.
RCT Entities:
BACKGROUND:Diabetic foot ulcer is one of the common complications of diabetes disease that is costly and difficult to treat. This problem can lead to morbidity and even mortality. Ozone is a gas that can optimize cellular metabolism and, because of its antioxidant and antibacterial effects, can help the better healing of diabetic foot ulcer. METHOD: Two hundred patients, aged 18-85 with diabetic foot ulcers ranging from grade 1 to 4 according to Wagner classification in two groups were studied. Group 1 was treated by full ozone therapy besides the standard regular DFU treatment while group two just was received routine diabetic foot care. Wound size, wound grade, healing time, Fasting blood sugar and inflammatory biomarker before and after treatment were checked. RESULTS: All patients have had complete wound closure in the ozone group. The mean age of the patients included in the results was 59.03 ± 12.593 and 53.5 ± 10.212 for ozone group and control group. The baseline average surface area of ulcers was 13.41 ± 14.092 cm2 (range 1-70 cm2) in ozone group and 12.72 ± 0.911 (range 1_64 cm2) in the control group. Average healing time was 69.44 ± 36.055 days (range 15-180 days), which is significantly lower than the median healing time measured in the control group and some previous studies. CONCLUSION: Our study results support the efficacy of ozone therapy especially in its comprehensive use in DFU healing and reduction in the chances of infection and amputation.
Authors: Jorge A Berlanga-Acosta; Gerardo E Guillén-Nieto; Nadia Rodríguez-Rodríguez; Yssel Mendoza-Mari; Maria Luisa Bringas-Vega; Jorge O Berlanga-Saez; Diana García Del Barco Herrera; Indira Martinez-Jimenez; Sandra Hernandez-Gutierrez; Pedro A Valdés-Sosa Journal: Front Endocrinol (Lausanne) Date: 2020-09-16 Impact factor: 5.555
Authors: Vanessa Silva; Cecília Peirone; Joana S Amaral; Rosa Capita; Carlos Alonso-Calleja; José A Marques-Magallanes; Ângela Martins; Águeda Carvalho; Luís Maltez; José Eduardo Pereira; José Luís Capelo; Gilberto Igrejas; Patrícia Poeta Journal: Molecules Date: 2020-08-07 Impact factor: 4.411