Betzi Pantoja-Torres1, Carlos J Toro-Huamanchumo2, Diego Urrunaga-Pastor3, Mirella Guarnizo-Poma4, Herbert Lazaro-Alcantara5, Socorro Paico-Palacios6, Vitalia Del Carmen Ranilla-Seguin7, Vicente A Benites-Zapata8. 1. Instituto Médico de la Mujer, Instituto Médico Metabólico, Lima, Peru. Electronic address: bpantoja@imm.com.pe. 2. Universidad San Ignacio de Loyola, Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Lima, Peru. Electronic address: toro2993@hotmail.com. 3. Universidad San Ignacio de Loyola, Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Lima, Peru. Electronic address: diego.urrunaga.pastor1@gmail.com. 4. Instituto Médico de la Mujer, Instituto Médico Metabólico, Lima, Peru. Electronic address: mguarnizo@imm.com.pe. 5. Instituto Médico de la Mujer, Instituto Médico Metabólico, Lima, Peru. Electronic address: hlazaro@imm.com.pe. 6. Instituto Médico de la Mujer, Instituto Médico Metabólico, Lima, Peru. Electronic address: spaico@imm.com.pe. 7. Instituto Médico de la Mujer, Instituto Médico Metabólico, Lima, Peru. Electronic address: vranilla@imm.com.pe. 8. Universidad San Ignacio de Loyola, Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Lima, Peru. Electronic address: vbeniteszapata@gmail.com.
Abstract
AIM: To evaluate the association between high triglyceride/HDL-cholesterol (TG/HDL-C) ratio and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in normal-weight healthy adults. METHODS: We carried out an analytical cross-sectional study in euthyroid non-diabetic adults, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high TG/HDL-C ratio, IR or hyperinsulinemia after OGTT. TG/HDL-C ratio values ≥ 3 were considered as high. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value ≥ 2.28 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high TG/HDL-C ratio and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). RESULTS: We analyzed the data of 118 individuals. Prevalence of high TG/HDL-C ratio was 17.8% (n = 21) while the prevalence of IR and hyperinsulinemia after OGTT was 24.6% (n = 29) and 17.0% (n = 20), respectively. TG/HDL-C-ratio values were positively correlated with HOMA-IR (r = 0.498; p < 0.01) and serum insulin after OGTT (r = 0.326; p < 0.001). In the adjusted model, high TG/HDL-C ratio was associated with both IR (aPR = 3.16; 95%CI: 1.80-5.77) and hyperinsulinemia after OGTT (aPR = 2.36; 95%CI: 1.20-4.63). CONCLUSIONS: High TG/HDL-C ratio was associated with both IR markers used in our study, appearing to be a clinically useful tool to assess IR in euthyroid normal-weight adults without type 2 diabetes mellitus.
AIM: To evaluate the association between high triglyceride/HDL-cholesterol (TG/HDL-C) ratio and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in normal-weight healthy adults. METHODS: We carried out an analytical cross-sectional study in euthyroid non-diabetic adults, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high TG/HDL-C ratio, IR or hyperinsulinemia after OGTT. TG/HDL-C ratio values ≥ 3 were considered as high. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value ≥ 2.28 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high TG/HDL-C ratio and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). RESULTS: We analyzed the data of 118 individuals. Prevalence of high TG/HDL-C ratio was 17.8% (n = 21) while the prevalence of IR and hyperinsulinemia after OGTT was 24.6% (n = 29) and 17.0% (n = 20), respectively. TG/HDL-C-ratio values were positively correlated with HOMA-IR (r = 0.498; p < 0.01) and serum insulin after OGTT (r = 0.326; p < 0.001). In the adjusted model, high TG/HDL-C ratio was associated with both IR (aPR = 3.16; 95%CI: 1.80-5.77) and hyperinsulinemia after OGTT (aPR = 2.36; 95%CI: 1.20-4.63). CONCLUSIONS: High TG/HDL-C ratio was associated with both IR markers used in our study, appearing to be a clinically useful tool to assess IR in euthyroid normal-weight adults without type 2 diabetes mellitus.
Authors: Nidhi H Patel; Michael T Osborne; Heather Teague; Philip Parel; Mariya Svirydava; Alexander V Sorokin; Meron Teklu; Grigory Manyak; Wunan Zhou; Carla Pantoja; Colin Scott; Martin P Playford; Promita Kapoor; Justin A Rodante; Andrew Keel; Marcus Chen; Ahmed Tawakol; Nehal N Mehta Journal: Atherosclerosis Date: 2021-11-08 Impact factor: 5.162
Authors: Benjamin I Perry; Frederik Vandenberghe; Nathalia Garrido-Torres; Emanuele F Osimo; Marianna Piras; Javier Vazquez-Bourgon; Rachel Upthegrove; Claire Grosu; Victor Ortiz-Garcia De La Foz; Peter B Jones; Nermine Laaboub; Miguel Ruiz-Veguilla; Jan Stochl; Celine Dubath; Manuel Canal-Rivero; Pavan Mallikarjun; Aurélie Reymond-Delacrétaz; Nicolas Ansermot; Emilio Fernandez-Egea; Severine Crettol; Franziska Gamma; Kerstin J Plessen; Philippe Conus; Golam M Khandaker; Graham K Murray; Chin B Eap; Benedicto Crespo-Facorro Journal: Lancet Reg Health Eur Date: 2022-08-19