Carlos J Toro-Huamanchumo1, Diego Urrunaga-Pastor2, Mirella Guarnizo-Poma3, Herbert Lazaro-Alcantara4, Socorro Paico-Palacios5, Betzi Pantoja-Torres6, Vitalia Del Carmen Ranilla-Seguin7, Vicente A Benites-Zapata8. 1. Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Peru. Electronic address: toro2993@hotmail.com. 2. Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Peru. Electronic address: diego.urrunaga.pastor1@gmail.com. 3. Instituto Médico de la Mujer, Instituto Médico Metabólico, Lima, Peru. Electronic address: mguarnizo@imm.com.pe. 4. Instituto Médico de la Mujer, Instituto Médico Metabólico, Lima, Peru. Electronic address: hlazaro@imm.com.pe. 5. Instituto Médico de la Mujer, Instituto Médico Metabólico, Lima, Peru. Electronic address: spaico@imm.com.pe. 6. Instituto Médico de la Mujer, Instituto Médico Metabólico, Lima, Peru. Electronic address: bpantoja@imm.com.pe. 7. Instituto Médico de la Mujer, Instituto Médico Metabólico, Lima, Peru. Electronic address: vranilla@imm.com.pe. 8. Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Peru. Electronic address: vbeniteszapata@gmail.com.
Abstract
AIM: To assess the association between elevated triglycerides/glucose index (TGI) and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in a sample of healthy adults. METHODS: We conducted an analytical cross-sectional study in euthyroid non-diabetic adults, who attended the outpatient service of a private clinic in Lima-Peru during the 2012-2016 period. Participants were categorized in two groups according to the presence or absence of elevated TGI, IR or hyperinsulinemia after OGTT. A TGI value ≥ 8.65 was considered as elevated. We defined IR as a Homeostasis Model Assessment (HOMA-IR) value ≥ 2.28 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson regression models to assess the association between elevated TGI and IR or hyperinsulinemia after OGTT. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). RESULTS: We analyzed 118 individuals, the average age was 37.5 ± 11.3 years, 21 (17.8%) were males and the median BMI was 22.7 ± 1.6 kg/m2. The prevalence of elevated TGI was 25.4% (n=30) while the prevalence of IR and hyperinsulinemia after OGTT was 24.6% (n=29) and 17.0% (n=20) respectively. In the adjusted model, elevated TGI was associated with both IR (aPR=6.36; 95%CI: 3.41-11.86) and hyperinsulinemia after OGTT (aPR=4.19; 95%CI: 1.81-9.70). CONCLUSIONS: We found that elevated TGI was associated with both IR markers in a sample of euthyroid adults without T2DM and with a normal BMI. The simplicity of the TGI calculation makes it the first-choice alternative when the hyperinsulinemic-euglycemic clamp or HOMA-IR are not available.
AIM: To assess the association between elevated triglycerides/glucose index (TGI) and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in a sample of healthy adults. METHODS: We conducted an analytical cross-sectional study in euthyroid non-diabetic adults, who attended the outpatient service of a private clinic in Lima-Peru during the 2012-2016 period. Participants were categorized in two groups according to the presence or absence of elevated TGI, IR or hyperinsulinemia after OGTT. A TGI value ≥ 8.65 was considered as elevated. We defined IR as a Homeostasis Model Assessment (HOMA-IR) value ≥ 2.28 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson regression models to assess the association between elevated TGI and IR or hyperinsulinemia after OGTT. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). RESULTS: We analyzed 118 individuals, the average age was 37.5 ± 11.3 years, 21 (17.8%) were males and the median BMI was 22.7 ± 1.6 kg/m2. The prevalence of elevated TGI was 25.4% (n=30) while the prevalence of IR and hyperinsulinemia after OGTT was 24.6% (n=29) and 17.0% (n=20) respectively. In the adjusted model, elevated TGI was associated with both IR (aPR=6.36; 95%CI: 3.41-11.86) and hyperinsulinemia after OGTT (aPR=4.19; 95%CI: 1.81-9.70). CONCLUSIONS: We found that elevated TGI was associated with both IR markers in a sample of euthyroid adults without T2DM and with a normal BMI. The simplicity of the TGI calculation makes it the first-choice alternative when the hyperinsulinemic-euglycemic clamp or HOMA-IR are not available.
Authors: Halil İbrahim Biter; Muhsin Kalyoncuoğlu; Aydın Rodi Tosu; Sinem Çakal; Ziya Apaydın; Ayça Gümüşdağ; Tufan Çınar; Ferhat Eyüpkoca; Erdal Belen; Mehmet Mustafa Can Journal: Rev Assoc Med Bras (1992) Date: 2022-09 Impact factor: 1.712
Authors: Rui Huang; Zi Cheng; Xingyi Jin; Xuemin Yu; Jinhui Yu; Yunpeng Guo; Li Zong; Jie Sheng; Xing Liu; Sufang Wang Journal: Ann Med Date: 2022-12 Impact factor: 4.709
Authors: Federico Belladelli; Luca Boeri; Edoardo Pozzi; Giuseppe Fallara; Christian Corsini; Luigi Candela; Walter Cazzaniga; Daniele Cignoli; Luca Pagliardini; Alessia D'Arma; Paolo Capogrosso; Eugenio Ventimiglia; Francesco Montorsi; Andrea Salonia Journal: Metabolites Date: 2022-02-03