| Literature DB >> 30639447 |
Dongyan Pan1, Xin Chang2, Mengqiao Xu3, Mingke Zhang4, Shoumei Zhang5, Yue Wang2, Xueting Luo6, Jiajun Xu7, Xiangqun Yang8, Xiaodong Sun3.
Abstract
Traumatic optic neuropathy or glaucoma lead to retinal ganglion cells loss and cause blindness, and there is no effective therapy strategy by far. Mesenchymal cells from the Wharton's jelly of the umbilical cord (umbilical cord mesenchymal stem cells, UMSCs) and UMSC-derived exosomes (UMSC-Exos) are promising candidates for allogeneic therapy in regenerative medicine, but their effort on optic nerve injury and the underlying mechanism remains undefined. In the present study, we investigated the functions of UMSC-Exos in a rat optic nerve crush (ONC) model. After three times of treatments with an interval of one week, we found that the UMSC-Exos significantly promoted Brn3a+ retinal ganglion cells (RGCs) survival in retinal ganglion cell layer compared with PBS controls. UMSC-Exos also significantly promoted GFAP+ glia cells activation in retina and optic nerve. However, no increase of GAP43+ axon counts in the optic nerve was found after UMSC-Exos treatment. Thus, our results demonstrate that UMSC-derived exosomes may play a role in neuroprotection by promoting the RGCs survival and glia cells activation but not the axon regeneration.Entities:
Keywords: Exosomes; Glia cells; Mesenchymal cells; Optic nerve crush; Retinal ganglion cells; Wharton’s jelly
Mesh：
Year: 2019 PMID： 30639447 DOI： 10.1016/j.jchemneu.2019.01.006
Source DB: PubMed Journal: J Chem Neuroanat ISSN： 0891-0618 Impact factor: 3.052