PURPOSE: Swept-source optical coherence tomography angiography (SS-OCTA) was used to measure the age-dependent changes in macular choriocapillaris (CC) flow deficits (FDs) in normal eyes. DESIGN: A prospective, cross-sectional study. METHODS: Subjects with normal eyes ranging in age from their 20s to their 80s were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000, Carl Zeiss Meditec, Dublin, California, USA). Both 3 × 3-mm and 6 × 6-mm scans were used to image the macular CC. Visualization of the CC and quantification of FDs were performed using a previously validated algorithm. The percentage of FDs (FD%) in the central 1-mm circle (C1), 1.5-mm rim (R1.5), and 2.5-mm circle (C2.5) from the 3 × 3-mm and 6 × 6-mm scans and FD% in the 2.5-mm rim (R2.5) and 5-mm circle (C5) from the 6 × 6-mm scans were measured and correlated with age and axial length. RESULTS: A total of 164 subjects were enrolled, with at least 10 subjects from each decade of life. No meaningful correlations were found between FD% and axial length (|r| < 0.30). FD% in all fields increased with increasing age (all r > 0.50; all P < .001); however, the greatest increases were found in the central macula C1 regions and the smallest increases in the peripheral macula R2.5 regions. CONCLUSIONS: In normal aging, the FD% increased with age across the central 5 mm of the macula, but the greatest increase was found in the central 1-mm region of the macula.
PURPOSE: Swept-source optical coherence tomography angiography (SS-OCTA) was used to measure the age-dependent changes in macular choriocapillaris (CC) flow deficits (FDs) in normal eyes. DESIGN: A prospective, cross-sectional study. METHODS: Subjects with normal eyes ranging in age from their 20s to their 80s were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000, Carl Zeiss Meditec, Dublin, California, USA). Both 3 × 3-mm and 6 × 6-mm scans were used to image the macular CC. Visualization of the CC and quantification of FDs were performed using a previously validated algorithm. The percentage of FDs (FD%) in the central 1-mm circle (C1), 1.5-mm rim (R1.5), and 2.5-mm circle (C2.5) from the 3 × 3-mm and 6 × 6-mm scans and FD% in the 2.5-mm rim (R2.5) and 5-mm circle (C5) from the 6 × 6-mm scans were measured and correlated with age and axial length. RESULTS: A total of 164 subjects were enrolled, with at least 10 subjects from each decade of life. No meaningful correlations were found between FD% and axial length (|r| < 0.30). FD% in all fields increased with increasing age (all r > 0.50; all P < .001); however, the greatest increases were found in the central macula C1 regions and the smallest increases in the peripheral macula R2.5 regions. CONCLUSIONS: In normal aging, the FD% increased with age across the central 5 mm of the macula, but the greatest increase was found in the central 1-mm region of the macula.
Authors: Eric Moult; WooJhon Choi; Nadia K Waheed; Mehreen Adhi; ByungKun Lee; Chen D Lu; Vijaysekhar Jayaraman; Benjamin Potsaid; Philip J Rosenfeld; Jay S Duker; James G Fujimoto Journal: Ophthalmic Surg Lasers Imaging Retina Date: 2014 Nov-Dec Impact factor: 1.300
Authors: Yingying Shi; Qinqin Zhang; Fang Zheng; Jonathan F Russell; Elie H Motulsky; James T Banta; Zhongdi Chu; Hao Zhou; Nimesh A Patel; Luis de Sisternes; Mary K Durbin; William Feuer; Giovanni Gregori; Ruikang K Wang; Philip J Rosenfeld Journal: Am J Ophthalmol Date: 2019-09-25 Impact factor: 5.258
Authors: Julia Schottenhamml; Eric M Moult; Stefan B Ploner; Siyu Chen; Eduardo Novais; Lennart Husvogt; Jay S Duker; Nadia K Waheed; James G Fujimoto; Andreas K Maier Journal: Biomed Opt Express Date: 2020-12-08 Impact factor: 3.732
Authors: Hao Zhou; Yining Dai; Yingying Shi; Jonathan F Russell; Cancan Lyu; Jila Noorikolouri; William J Feuer; Zhongdi Chu; Qinqin Zhang; Luis de Sisternes; Mary K Durbin; Giovanni Gregori; Philip J Rosenfeld; Ruikang K Wang Journal: Ophthalmol Retina Date: 2019-10-01
Authors: Yingying Shi; Zhongdi Chu; Liang Wang; Qinqin Zhang; William Feuer; Luis de Sisternes; Mary K Durbin; Giovanni Gregori; Ruikang K Wang; Philip J Rosenfeld Journal: Am J Ophthalmol Date: 2020-07-02 Impact factor: 5.258
Authors: Zhongdi Chu; Qinqin Zhang; Giovanni Gregori; Philip J Rosenfeld; Ruikang K Wang Journal: Am J Ophthalmol Date: 2020-09-04 Impact factor: 5.258