Alexander E Merkler1, Javid Alakbarli2, Gino Gialdini3, Babak B Navi4, Santosh B Murthy4, Parag Goyal2, Jiwon Kim2, Richard B Devereux2, Monika M Safford2, Costantino Iadecola4, Hooman Kamel4, Jonathan W Weinsaft2. 1. Department of Neurology, Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York. Electronic address: alm9097@med.cornell.edu. 2. Department of Medicine, Weill Cornell Medicine, New York, New York. 3. Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York. 4. Department of Neurology, Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York.
Abstract
BACKGROUND: The short-term risk of ischemic stroke in patients with left ventricular (LV) thrombus identified via delayed-enhancement cardiac magnetic resonance (DE-CMR) imaging is uncertain. METHODS: We performed a retrospective cohort study of patients who underwent DE-CMR for evaluation of LV systolic dysfunction at NewYork-Presbyterian Hospital/Weill Cornell between 2007 and 2016. We identified all hospitalized patients who had DE-CMR evidence of LV thrombus, and as controls, all hospitalized patients who had no DE-CMR evidence of LV thrombus; 2 control patients were randomly selected for each patient with LV thrombus. Our primary outcome was ischemic stroke prior to hospital discharge. Additionally, we compared the risk of stroke among patients with: (1) no LV thrombus, (2) LV thrombus by DE-CMR but not by echocardiography, and (3) LV thrombus by both DE-CMR and echocardiography. RESULTS: We identified 33 patients with LV thrombus and 66 patients without LV thrombus on DE-CMR. Of the 33 patients with LV thrombus on DE-CMR, 13 had echocardiographic evidence of thrombus. Ischemic stroke occurred in 3 of 33 (9.1%; 95% CI, 1.9%-24.3%) patients with LV thrombus on DE-CMR. Ischemic stroke occurred in 0 of 66 (0%; 95% CI, 0%-5.4%) patients without LV thrombus on DE-CMR, 1 of 20 (5.0%; 95% CI, .1%-24.9%) patients with thrombus on DE-CMR but not echocardiogram, and 2 of 13 (15.4%; 95% CI, 1.9%-45.4%) patients with thrombus on both DE-CMR and echocardiogram (P value for comparison among groups, .02). CONCLUSIONS: We found a 9% short-term risk of ischemic stroke in patients with LV thrombus detected on DE-CMR.
BACKGROUND: The short-term risk of ischemic stroke in patients with left ventricular (LV) thrombus identified via delayed-enhancement cardiac magnetic resonance (DE-CMR) imaging is uncertain. METHODS: We performed a retrospective cohort study of patients who underwent DE-CMR for evaluation of LV systolic dysfunction at NewYork-Presbyterian Hospital/Weill Cornell between 2007 and 2016. We identified all hospitalized patients who had DE-CMR evidence of LV thrombus, and as controls, all hospitalized patients who had no DE-CMR evidence of LV thrombus; 2 control patients were randomly selected for each patient with LV thrombus. Our primary outcome was ischemic stroke prior to hospital discharge. Additionally, we compared the risk of stroke among patients with: (1) no LV thrombus, (2) LV thrombus by DE-CMR but not by echocardiography, and (3) LV thrombus by both DE-CMR and echocardiography. RESULTS: We identified 33 patients with LV thrombus and 66 patients without LV thrombus on DE-CMR. Of the 33 patients with LV thrombus on DE-CMR, 13 had echocardiographic evidence of thrombus. Ischemic stroke occurred in 3 of 33 (9.1%; 95% CI, 1.9%-24.3%) patients with LV thrombus on DE-CMR. Ischemic stroke occurred in 0 of 66 (0%; 95% CI, 0%-5.4%) patients without LV thrombus on DE-CMR, 1 of 20 (5.0%; 95% CI, .1%-24.9%) patients with thrombus on DE-CMR but not echocardiogram, and 2 of 13 (15.4%; 95% CI, 1.9%-45.4%) patients with thrombus on both DE-CMR and echocardiogram (P value for comparison among groups, .02). CONCLUSIONS: We found a 9% short-term risk of ischemic stroke in patients with LV thrombus detected on DE-CMR.
Authors: Nico R Mollet; Steven Dymarkowski; Wim Volders; Jurgen Wathiong; Lieven Herbots; Frank E Rademakers; Jan Bogaert Journal: Circulation Date: 2002-12-03 Impact factor: 29.690
Authors: Burkhard Sievers; Michael D Elliott; Lynne M Hurwitz; Timothy S E Albert; Igor Klem; Wolfgang G Rehwald; Michele A Parker; Robert M Judd; Raymond J Kim Journal: Circulation Date: 2007-01-02 Impact factor: 29.690
Authors: Monvadi B Srichai; Chelif Junor; L Leonardo Rodriguez; Arthur E Stillman; Richard A Grimm; Michael L Lieber; Joan A Weaver; Nicholas G Smedira; Richard D White Journal: Am Heart J Date: 2006-07 Impact factor: 4.749
Authors: Jonathan W Weinsaft; Raymond J Kim; Michael Ross; Daniel Krauser; Shant Manoushagian; Troy M LaBounty; Matthew D Cham; James K Min; Kirsten Healy; Yi Wang; Michele Parker; Mary J Roman; Richard B Devereux Journal: JACC Cardiovasc Imaging Date: 2009-08
Authors: Pratik S Velangi; Christopher Choo; Ko-Hsuan A Chen; Felipe Kazmirczak; Prabhjot S Nijjar; Afshin Farzaneh-Far; Osama Okasha; Mehmet Akçakaya; Jonathan W Weinsaft; Chetan Shenoy Journal: Circ Cardiovasc Imaging Date: 2019-11-11 Impact factor: 7.792
Authors: Donya A Alhassan; Khawaja Bilal Waheed; Muhammad N Sharif; Muhammad Z Ul Hassan; Fazal Ghaffar; Khaled S Salem; Emad F M Said; Bayan M Altalaq; Ahmad O Qarmash; Zechariah J Arulanantham Journal: J Saudi Heart Assoc Date: 2020-08-17