| Literature DB >> 30638875 |
Christophe D Guillon1, Yi-Hua Jan2, Natalie Foster3, Joel Ressner3, Diane E Heck4, Jeffrey D Laskin2, Ned D Heindel3.
Abstract
Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.Entities:
Keywords: 8-MOP; 8-Methoxypsoralen; Dark-reaction toxicity; Keratinocytes; PAM212; Phototoxicity
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Year: 2018 PMID： 30638875 PMCID： PMC6364570 DOI： 10.1016/j.bmcl.2018.12.048
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823