Fumin Jia1, Aparna Wagle Shukla2, Wei Hu2, Leonardo Almeida2, Vanessa Holanda3, Jianguo Zhang4, Fangang Meng5, Michael S Okun2, Luming Li1,6,7,8. 1. National Engineering laboratory for Neuromodulation Tsinghua University Beijing China. 2. University of Florida Center for Movement Disorders and Neurorestoration Gainesville FL USA. 3. Department of Neurosurgery University of Florida Gainesville FL USA. 4. Beijing Tiantan Hospital Capital Medical University Beijing China. 5. Beijing Neurosurgical Institute Capital Medical University Beijing China. 6. Precision Medicine & Healthcare Research Center Tsinghua-Berkeley Shenzhen Institute Shenzhen China. 7. Man-machine-environment engineering Institute, School of Aerospace Engineering Tsinghua university Beijing China. 8. Center of Epilepsy Beijing Institute for Brain Disorders Beijing China.
Abstract
INTRODUCTION: Deep brain stimulation (DBS) with high frequency (HFS) is a well-established therapy for Parkinson's disease (PD); however, low frequency DBS (LFS) may control axial symptoms including freezing of gait (FOG). We conducted a pilot safety and feasibility study to examine if a novel DBS paradigm of variable frequency stimulation (VFS) that combined HFS and LFS would capture a broader set of motor symptoms. METHODS: Four PD patients with bilateral STN DBS and FOG were enrolled. A UPDRS III and 10 m timed up and go (TUG) task were performed off medications-off DBS and then one hour after HFS and one hour after VFS programming. RESULTS: The UPDRS III motor score improved by additional 14% during VFS setting when compared to HFS. VFS also increased gait speed (mean change 45%) and reduced the number of freezing episodes (mean change 58%). CONCLUSIONS: VFS improves UPDRS and FOG in PD when compared to HFS.
INTRODUCTION: Deep brain stimulation (DBS) with high frequency (HFS) is a well-established therapy for Parkinson's disease (PD); however, low frequency DBS (LFS) may control axial symptoms including freezing of gait (FOG). We conducted a pilot safety and feasibility study to examine if a novel DBS paradigm of variable frequency stimulation (VFS) that combined HFS and LFS would capture a broader set of motor symptoms. METHODS: Four PD patients with bilateral STN DBS and FOG were enrolled. A UPDRS III and 10 m timed up and go (TUG) task were performed off medications-off DBS and then one hour after HFS and one hour after VFS programming. RESULTS: The UPDRS III motor score improved by additional 14% during VFS setting when compared to HFS. VFS also increased gait speed (mean change 45%) and reduced the number of freezing episodes (mean change 58%). CONCLUSIONS: VFS improves UPDRS and FOG in PD when compared to HFS.
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