Xue-Jie Wang1, Wei Xu2, Jie-Qiong Li1, Xi-Peng Cao3, Lan Tan1,2, Jin-Tai Yu1,4. 1. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China. 2. College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China. 3. Clinical Research Center, Qingdao Municipal Hospital, Qingdao University, Qingdao, China. 4. Department of Neurology, Huashan Hospital, Fudan University, China.
Abstract
BACKGROUND: Early-life environment is related to childhood brain development and cognitive function in later life. However, the associations of early-life risk factors with dementia and cognitive impairment were still controversial. OBJECTIVE: Our study aims to investigate early-life risk factors for dementia and cognitive impairment. METHODS: PubMed and Cochrane Library were searched to identify prospective cohort and retrospective case-control studies exploring early-life factors for dementia and cognitive impairment. Pooled effect estimates for each factor were calculated by random-effect model. RESULTS: Thirty-seven studies with 46,727 participants were included. The pooled results indicated significant associations of dementia with food deficiency (OR = 2.05, 95% CI = 1. 22-3.44), low education level (RR = 1.80, 95% CI = 1.60-2.02), and shorter leg length (OR = 1.19, 95% CI = 1.07-1.32). Other potential risk factors identified in the systematic review include rural residence, number of siblings, history of head trauma, early parental death or re-marriage, and poor learning ability. CONCLUSION: Early-life factors, including education level, leg length, history of childhood head trauma, family-related factors and learning ability, were associated with the risk of dementia and cognitive impairment in later life. Further high-quality longitudinal studies are needed to verify the causality between early-life risk factors and dementia and cognitive impairment.
BACKGROUND: Early-life environment is related to childhood brain development and cognitive function in later life. However, the associations of early-life risk factors with dementia and cognitive impairment were still controversial. OBJECTIVE: Our study aims to investigate early-life risk factors for dementia and cognitive impairment. METHODS: PubMed and Cochrane Library were searched to identify prospective cohort and retrospective case-control studies exploring early-life factors for dementia and cognitive impairment. Pooled effect estimates for each factor were calculated by random-effect model. RESULTS: Thirty-seven studies with 46,727 participants were included. The pooled results indicated significant associations of dementia with food deficiency (OR = 2.05, 95% CI = 1. 22-3.44), low education level (RR = 1.80, 95% CI = 1.60-2.02), and shorter leg length (OR = 1.19, 95% CI = 1.07-1.32). Other potential risk factors identified in the systematic review include rural residence, number of siblings, history of head trauma, early parental death or re-marriage, and poor learning ability. CONCLUSION: Early-life factors, including education level, leg length, history of childhood head trauma, family-related factors and learning ability, were associated with the risk of dementia and cognitive impairment in later life. Further high-quality longitudinal studies are needed to verify the causality between early-life risk factors and dementia and cognitive impairment.
Authors: Miguel Germán Borda; José Manuel Santacruz; Dag Aarsland; Sandy Camargo-Casas; Carlos Alberto Cano-Gutierrez; Silvia Suárez-Monsalve; Santiago Campos-Fajardo; Mario Ulises Pérez-Zepeda Journal: Eur Geriatr Med Date: 2019-04-03 Impact factor: 1.710
Authors: Ronald M Lazar; Virginia J Howard; Walter N Kernan; Hugo J Aparicio; Deborah A Levine; Anthony J Viera; Lori C Jordan; David L Nyenhuis; Katherine L Possin; Farzaneh A Sorond; Carole L White Journal: Stroke Date: 2021-03-15 Impact factor: 7.914
Authors: Elena Lobo; Patricia Gracia-García; Antonio Lobo; Pedro Saz; Concepción De-la-Cámara Journal: Int J Environ Res Public Health Date: 2021-07-02 Impact factor: 3.390
Authors: Martin Lövdén; Laura Fratiglioni; M Maria Glymour; Ulman Lindenberger; Elliot M Tucker-Drob Journal: Psychol Sci Public Interest Date: 2020-08