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Literature DB >> 30633906

An Allosteric Switch Primes Sequence-Specific DNA Recognition.

Abstract

Regulation of protein-DNA binding specificity occurs through myriad mechanisms. Boudet et al. discover yet a new form of specificity through allosteric regulation, an ATP-induced structural switch that mediates specific DNA recognition in an archaeoeukaryotic primase.

Entities: Chemical Gene Species

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Year: 2019 PMID： 30633906 PMCID： PMC6532627 DOI： 10.1016/j.cell.2018.12.020

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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References

10 in total

1. A Small Helical Bundle Prepares Primer Synthesis by Binding Two Nucleotides that Enhance Sequence-Specific Recognition of the DNA Template.

Authors: Julien Boudet; Jean-Christophe Devillier; Thomas Wiegand; Loic Salmon; Beat H Meier; Georg Lipps; Frédéric H-T Allain
Journal: Cell Date: 2018-12-27 Impact factor: 41.582

2. Interaction of ribonucleoside triphosphates with the gene 4 primase of bacteriophage T7.

Authors: D N Frick; S Kumar; C C Richardson
Journal: J Biol Chem Date: 1999-12-10 Impact factor: 5.157

3. Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.

Authors: Andrey G Baranovskiy; Nigar D Babayeva; Yinbo Zhang; Jianyou Gu; Yoshiaki Suwa; Youri I Pavlov; Tahir H Tahirov
Journal: J Biol Chem Date: 2016-03-14 Impact factor: 5.157

4. Murine DNA polymerase.alpha-primase initiates RNA-primed DNA synthesis preferentially upstream of a 3'-CC(C/A)-5' motif.

Authors: S K Davey; E A Faust
Journal: J Biol Chem Date: 1990-03-05 Impact factor: 5.157

An Allosteric Switch Primes Sequence-Specific DNA Recognition.

1. A Small Helical Bundle Prepares Primer Synthesis by Binding Two Nucleotides that Enhance Sequence-Specific Recognition of the DNA Template.

2. Interaction of ribonucleoside triphosphates with the gene 4 primase of bacteriophage T7.

3. Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.

4. Murine DNA polymerase.alpha-primase initiates RNA-primed DNA synthesis preferentially upstream of a 3'-CC(C/A)-5' motif.

Review 5. Mechanism and evolution of DNA primases.

6. Non-DNA-binding cofactors enhance DNA-binding specificity of a transcriptional regulatory complex.

7. The archaeo-eukaryotic primase of plasmid pRN1 requires a helix bundle domain for faithful primer synthesis.

Review 8. Structures to complement the archaeo-eukaryotic primases catalytic cycle description: What's next?

9. Properties of an unusual DNA primase from an archaeal plasmid.

Review 10. Protein-DNA binding: complexities and multi-protein codes.