Craig A Bollig1, Jeffrey B Jorgensen1. 1. Department of Otolaryngology-Head and Neck Surgery, University of Missouri School of Medicine, Columbia, Missouri.
Abstract
BACKGROUND: The effect of treatment modality on long-term opioid dependence in patients with oropharyngeal cancer has not been reported. METHODS: A retrospective cohort of 122 patients with T1/T2 oropharyngeal cancer undergoing treatment was generated. Risk factors associated with chronic opioid use were investigated by univariate and multivariate analyses. RESULTS: The prevalence of chronic opioid use was 45.9%. On multivariate analysis, primary nonsurgical treatment (odds ratio [OR] 4.5, 95% confidence interval [CI]: 1.7-11.4), pretreatment opioid use (OR 14.9, 95% CI: 3.5-62.5), psychiatric disorder (OR 4.3, 95% CI: 1.03-18.5), alcohol use (OR 2.6, 95% CI: 1.03-6.5), and younger age (OR 1.1, 95% CI: 1.02-1.11) were significantly associated with chronic opioid use. CONCLUSION: Primary nonsurgical treatment, younger age, pretreatment opioid use, alcohol use, and psychiatric disorder were independently associated with an increased risk of chronic opioid use. Preventative strategies should be especially focused toward these patients to reduce their risk of long-term opioid use.
BACKGROUND: The effect of treatment modality on long-term opioid dependence in patients with oropharyngeal cancer has not been reported. METHODS: A retrospective cohort of 122 patients with T1/T2 oropharyngeal cancer undergoing treatment was generated. Risk factors associated with chronic opioid use were investigated by univariate and multivariate analyses. RESULTS: The prevalence of chronic opioid use was 45.9%. On multivariate analysis, primary nonsurgical treatment (odds ratio [OR] 4.5, 95% confidence interval [CI]: 1.7-11.4), pretreatment opioid use (OR 14.9, 95% CI: 3.5-62.5), psychiatric disorder (OR 4.3, 95% CI: 1.03-18.5), alcohol use (OR 2.6, 95% CI: 1.03-6.5), and younger age (OR 1.1, 95% CI: 1.02-1.11) were significantly associated with chronic opioid use. CONCLUSION: Primary nonsurgical treatment, younger age, pretreatment opioid use, alcohol use, and psychiatric disorder were independently associated with an increased risk of chronic opioid use. Preventative strategies should be especially focused toward these patients to reduce their risk of long-term opioid use.
Authors: Sondos Zayed; Cindy Lin; R Gabriel Boldt; Jinka Sathya; Varagur Venkatesan; Nancy Read; Lucas C Mendez; Dwight E Moulin; David A Palma Journal: Adv Radiat Oncol Date: 2020-10-26
Authors: Craig A Bollig; Christopher I Newberry; Tabitha L I Galloway; Robert P Zitsch; Elyse K Hanly; Vivian L Zhu; Nitin Pagedar; Rohit Nallani; Andres M Bur; William C Spanos; Jeffrey B Jorgensen Journal: Laryngoscope Date: 2020-10-24 Impact factor: 3.325