| Literature DB >> 30622307 |
Sebastian Boeltz1, Poorya Amini2, Hans-Joachim Anders3, Felipe Andrade4, Rostyslav Bilyy5, Simon Chatfield6, Iwona Cichon7, Danielle M Clancy8, Jyaysi Desai3, Tetiana Dumych5, Nishant Dwivedi9,10, Rachael Ann Gordon11, Jonas Hahn1, Andrés Hidalgo12,13, Markus H Hoffmann14, Mariana J Kaplan15, Jason S Knight16, Elzbieta Kolaczkowska7, Paul Kubes17, Moritz Leppkes18, Angelo A Manfredi19, Seamus J Martin20, Christian Maueröder1,8, Norma Maugeri19, Ioannis Mitroulis21,22, Luis E Munoz1, Daigo Nakazawa3, Indira Neeli23, Victor Nizet24,25, Elmar Pieterse26, Marko Z Radic23, Christiane Reinwald1, Konstantinos Ritis21,22, Patrizia Rovere-Querini19, Michal Santocki7, Christine Schauer1, Georg Schett1, Mark Jay Shlomchik11, Hans-Uwe Simon2,27, Panagiotis Skendros21,22, Darko Stojkov2, Peter Vandenabeele8,28,29, Tom Vanden Berghe8,28,30, Johan van der Vlag26, Ljubomir Vitkov31,32, Maren von Köckritz-Blickwede33, Shida Yousefi2, Alexander Zarbock34, Martin Herrmann1.
Abstract
Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have been uncovered. Nowadays, the field continues to expand and novel mechanisms that orchestrate formation of NETs, their previously unknown properties, and novel implications in disease continue to emerge. The abundance of available data has also led to some confusion in the NET research community due to contradictory results and divergent scientific concepts, such as pro- and anti-inflammatory roles in pathologic conditions, demarcation from other forms of cell death, or the origin of the DNA that forms the NET scaffold. Here, we present prevailing concepts and state of the science in NET-related research and elaborate on open questions and areas of dispute.Mesh：
Year: 2019 PMID： 30622307 PMCID： PMC6370810 DOI： 10.1038/s41418-018-0261-x
Source DB: PubMed Journal: Cell Death Differ ISSN： 1350-9047 Impact factor: 15.828