Literature DB >> 30622032

Generation of four iPSC lines from peripheral blood mononuclear cells (PBMCs) of an attention deficit hyperactivity disorder (ADHD) individual and a healthy sibling in an Australia-Caucasian family.

Janette Tong1, Kyung Min Lee2, Xiaodong Liu3, Christian M Nefzger3, Prasidhee Vijayakumar4, Ziarih Hawi2, Ken C Pang5, Clare L Parish6, Jose M Polo3, Mark A Bellgrove2.   

Abstract

Peripheral blood mononuclear cells were donated by a male teenager with clinically diagnosed attention deficit hyperactivity disorder (ADHD) under the Diagnostic and Statistical Manual of Mental Disorders IV criteria and his unaffected male sibling. Induced pluripotent stem cells were developed using integration-free Sendai Reprogramming factors containing OCT4, SOX2, KLF4, and c-MYC. All four iPSC lines displayed pluripotent cell morphology, pluripotency-associated factors at the DNA and protein level, alkaline phosphatase enzymatic activity and a male karyotype of 46, XY. All lines had capacity for in vitro differentiation into all the three germ layers. All were negative for Mycoplasma.
Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

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Year:  2018        PMID: 30622032     DOI: 10.1016/j.scr.2018.11.014

Source DB:  PubMed          Journal:  Stem Cell Res        ISSN: 1873-5061            Impact factor:   2.020


  5 in total

1.  Promising Developments in the Use of Induced Pluripotent Stem Cells in Research of ADHD.

Authors:  Cristine Marie Yde Ohki; Rhiannon V McNeill; Matthias Nieberler; Franziska Radtke; Sarah Kittel-Schneider; Edna Grünblatt
Journal:  Curr Top Behav Neurosci       Date:  2022

Review 2.  Genetics in the ADHD Clinic: How Can Genetic Testing Support the Current Clinical Practice?

Authors:  Lívia Balogh; Attila J Pulay; János M Réthelyi
Journal:  Front Psychol       Date:  2022-03-08

Review 3.  Recent advances in understanding of attention deficit hyperactivity disorder (ADHD): how genetics are shaping our conceptualization of this disorder.

Authors:  Tetyana Zayats; Benjamin M Neale
Journal:  F1000Res       Date:  2019-12-05

Review 4.  Mental health dished up-the use of iPSC models in neuropsychiatric research.

Authors:  Rhiannon V McNeill; Georg C Ziegler; Franziska Radtke; Matthias Nieberler; Klaus-Peter Lesch; Sarah Kittel-Schneider
Journal:  J Neural Transm (Vienna)       Date:  2020-05-07       Impact factor: 3.575

Review 5.  Making Sense of Patient-Derived iPSCs, Transdifferentiated Neurons, Olfactory Neuronal Cells, and Cerebral Organoids as Models for Psychiatric Disorders.

Authors:  Jakob Unterholzner; Vincent Millischer; Christoph Wotawa; Akira Sawa; Rupert Lanzenberger
Journal:  Int J Neuropsychopharmacol       Date:  2021-10-23       Impact factor: 5.176

  5 in total

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