| Literature DB >> 30622032 |
Janette Tong1, Kyung Min Lee2, Xiaodong Liu3, Christian M Nefzger3, Prasidhee Vijayakumar4, Ziarih Hawi2, Ken C Pang5, Clare L Parish6, Jose M Polo3, Mark A Bellgrove2.
Abstract
Peripheral blood mononuclear cells were donated by a male teenager with clinically diagnosed attention deficit hyperactivity disorder (ADHD) under the Diagnostic and Statistical Manual of Mental Disorders IV criteria and his unaffected male sibling. Induced pluripotent stem cells were developed using integration-free Sendai Reprogramming factors containing OCT4, SOX2, KLF4, and c-MYC. All four iPSC lines displayed pluripotent cell morphology, pluripotency-associated factors at the DNA and protein level, alkaline phosphatase enzymatic activity and a male karyotype of 46, XY. All lines had capacity for in vitro differentiation into all the three germ layers. All were negative for Mycoplasma.Entities:
Mesh:
Year: 2018 PMID: 30622032 DOI: 10.1016/j.scr.2018.11.014
Source DB: PubMed Journal: Stem Cell Res ISSN: 1873-5061 Impact factor: 2.020