Ping-Huei Tsai1,2, Chin-Chean Wong3,4, Wing P Chan5,6, Tung-Wu Lu7. 1. Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan. 2. Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan. 3. Department of Orthopedics, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan. 4. Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 5. Department of Radiology, Wan Fang Hospital, Taipei Medical University, No. 111, Xinglong Road, Section 3, Taipei, 116, Taiwan. wingchan@tmu.edu.tw. 6. Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. wingchan@tmu.edu.tw. 7. Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
Abstract
OBJECTIVES: Our aim was to investigate the role of age, sex, and location on MR T2* values of the knee cartilage in asymptomatic controls and patients with osteoarthritis (OA). METHODS: A total of 100 participants, including 40 with OA and 60 asymptomatic controls, were enrolled in this study. Patients with OA were compared to age- (≥ 41 years old) and sex-matched controls. Controls were divided by age (aged 21-40 years, 41-60, ≥ 61). T2* values were acquired using a T2*-weighted fast gradient-echo sequence and a 1.5-T MRI scanner. T2* values of the femoral and tibial cartilages at the weight-bearing areas were obtained for comparisons. RESULTS: The T2* values significantly increased with age and were significantly higher in the medial femoral cartilage (35.96 ± 4.06 and 31.85 ± 2.44 ms), medial tibial cartilage (30.95 ± 2.87 and 28.24 ± 1.74 ms), and lateral femoral cartilage (33.90 ± 3.15 and 31.51 ± 2.28 ms) in OA patients versus age- and sex-matched controls. Among OA patients, the T2* values for women exceed those in men in the medial femoral cartilage (37.59 ± 4.43 and 34.16 ± 2.63 ms) and medial tibial cartilage (32.17 ± 2.59 and 29.62 ± 2.53 ms; p < 0.01). Correlations were found between the Lequesne index and the T2* values for the medial femoral cartilage (r = 0.636, p < 0.001) and the medial tibial cartilage (r = 0.433, p = 0.005). CONCLUSION: Cartilage T2* values tend to increase with age and are useful in assessing cartilage degeneration in early OA. KEY POINTS: • Age, sex, and location have important effects on cartilage T2* values at the knee. • MR T2* measurements are useful toward assessing cartilage degeneration. • The medial femoral and tibial cartilage T2* values correlate well with disease severity.
OBJECTIVES: Our aim was to investigate the role of age, sex, and location on MR T2* values of the knee cartilage in asymptomatic controls and patients with osteoarthritis (OA). METHODS: A total of 100 participants, including 40 with OA and 60 asymptomatic controls, were enrolled in this study. Patients with OA were compared to age- (≥ 41 years old) and sex-matched controls. Controls were divided by age (aged 21-40 years, 41-60, ≥ 61). T2* values were acquired using a T2*-weighted fast gradient-echo sequence and a 1.5-T MRI scanner. T2* values of the femoral and tibial cartilages at the weight-bearing areas were obtained for comparisons. RESULTS: The T2* values significantly increased with age and were significantly higher in the medial femoral cartilage (35.96 ± 4.06 and 31.85 ± 2.44 ms), medial tibial cartilage (30.95 ± 2.87 and 28.24 ± 1.74 ms), and lateral femoral cartilage (33.90 ± 3.15 and 31.51 ± 2.28 ms) in OA patients versus age- and sex-matched controls. Among OA patients, the T2* values for women exceed those in men in the medial femoral cartilage (37.59 ± 4.43 and 34.16 ± 2.63 ms) and medial tibial cartilage (32.17 ± 2.59 and 29.62 ± 2.53 ms; p < 0.01). Correlations were found between the Lequesne index and the T2* values for the medial femoral cartilage (r = 0.636, p < 0.001) and the medial tibial cartilage (r = 0.433, p = 0.005). CONCLUSION:Cartilage T2* values tend to increase with age and are useful in assessing cartilage degeneration in early OA. KEY POINTS: • Age, sex, and location have important effects on cartilage T2* values at the knee. • MR T2* measurements are useful toward assessing cartilage degeneration. • The medial femoral and tibial cartilage T2* values correlate well with disease severity.
Entities:
Keywords:
Cartilage; Diagnostic imaging; Knee; Magnetic resonance imaging (MRI); Osteoarthritis
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