| Literature DB >> 30612844 |
Mario Contin1, Claudia Sepúlveda2, Mirta Fascio3, Carlos A Stortz3, Elsa B Damonte4, Norma B D'Accorso5.
Abstract
In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested against Junín virus, etiological agent responsible of Argentine hemorrhagic fever. Some compounds inhibited Junín virus in the range of 13.2-389.1 µM. Two modified ribavirin analogues presented an effective concentration comparable to ribavirin but with a higher selectivity index.Entities:
Keywords: 1,2,3-Triazole ribose conjugates; Antiviral; Click chemistry; Junín virus
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Year: 2019 PMID： 30612844 DOI： 10.1016/j.bmcl.2018.12.063
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823