| Literature DB >> 30612538 |
Maurits G L Olthof1,2,3,4, Diederik H R Kempen5, Xifeng Liu1,2, Mahrokh Dadsetan1,2, Marianna A Tryfonidou3, Michael J Yaszemski1,2, Wouter J A Dhert3,4, Lichun Lu1,2.
Abstract
IMPACT STATEMENT: Biomaterials can play a dual role in bone regeneration: they enable local sustained delivery of growth factors, such as bone morphogenetic protein-2 (BMP-2), while they provide structural support as scaffold. By better imitating the properties of native bone tissue, scaffolds may be both osteoconductive and osteoinductive. The latter can be achieved by modifying the electrical charge of the surface. The present work uses tunable oligo[(polyethylene glycol) fumarate] hydrogel and demonstrates that negative charge enhances BMP-2-induced bone formation compared with neutral or positive charge. Altogether, this indicates that tissue-specific surface charge modifications of biomaterials hold great promise in the field of tissue regeneration.Entities:
Keywords: biomaterials; bone morphogenetic protein-2 release; bone tissue engineering; electrical charge; oligo[(polyethylene glycol) fumarate]; poly(lactic-co-glycolic acid)
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Year: 2019 PMID： 30612538 PMCID： PMC6648221 DOI： 10.1089/ten.TEA.2018.0140
Source DB: PubMed Journal: Tissue Eng Part A ISSN： 1937-3341 Impact factor: 3.845