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Literature DB >> 30610466

Slit/Robo Signaling Pathway in Cancer; a New Stand Point for Cancer Treatment.

Zahra Koohini¹, Zohreh Koohini², Shahram Teimourian³.

Abstract

Angiogenesis and metastasis are two critical steps for cancer cells survival and migration. The microenvironment of tumor sphere induces new blood vessels formation for enhancing tumor mass. Preexisting capillaries and postcapillary venules in tumors bring about new blood vessels. ROBO1-ROBO4 are transmembrane receptors family which act as guidance molecules of the nervous system. The SLITs family is secreted glycoproteins that bind to these receptors. SLIT-ROBO signaling pathway plays an important role in neurogenesis and immune response. Linkage between ROBOs and their ligands (SLITs) induce chemorepllent signal for regulation of axon guidance and leukocyte cell migration, recent finding shows that it is also involved in endothelial cell migration and angiogenesis in various type of cancers. In this article we review recent finding of SLIT-ROBO pathway in angiogenesis and metastasis.

Entities: Disease Gene

Keywords: Robo; Slite; Tumor angiogenesis; Tumor markers

Mesh：

Substances：

Year: 2019 PMID： 30610466 DOI： 10.1007/s12253-018-00568-y

Source DB: PubMed Journal: Pathol Oncol Res ISSN： 1219-4956 Impact factor: 3.201

80 in total

1. Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription.

Authors: Jinseol Rhee; Tim Buchan; Lawrence Zukerberg; Jack Lilien; Janne Balsamo
Journal: Nat Cell Biol Date: 2007-07-08 Impact factor: 28.824

Review 2. The role of Slit-Robo signaling in the regulation of tissue barriers.

Authors: Ming-Fang Wu; Chen-Yi Liao; Ling-Yi Wang; Jinghua Tsai Chang
Journal: Tissue Barriers Date: 2017-06-08

3. Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : I. Zygotic loci on the second chromosome.

Authors: C Nüsslein-Volhard; E Wieschaus; H Kluding
Journal: Wilehm Roux Arch Dev Biol Date: 1984-09

Review 4. Slit-Robo signaling.

Authors: Heike Blockus; Alain Chédotal
Journal: Development Date: 2016-09-01 Impact factor: 6.868

5. VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin.

Authors: Julie Gavard; J Silvio Gutkind
Journal: Nat Cell Biol Date: 2006-10-22 Impact factor: 28.824

6. Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression.

Authors: R Salcedo; M L Ponce; H A Young; K Wasserman; J M Ward; H K Kleinman; J J Oppenheim; W J Murphy
Journal: Blood Date: 2000-07-01 Impact factor: 22.113

7. Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis.

Authors: G P Holmes; K Negus; L Burridge; S Raman; E Algar; T Yamada; M H Little
Journal: Mech Dev Date: 1998-12 Impact factor: 1.882

8. A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium.

Authors: Yoshiaki Okada; Kiichiro Yano; Enjing Jin; Nobuaki Funahashi; Mie Kitayama; Takefumi Doi; Katherine Spokes; David L Beeler; Shu-Ching Shih; Hitomi Okada; Tatyana A Danilov; Elizabeth Maynard; Takashi Minami; Peter Oettgen; William C Aird
Journal: Circ Res Date: 2007-05-10 Impact factor: 17.367

4. Expression patterns of SLIT/ROBO mRNAs reveal a characteristic feature in the entorhinal-hippocampal area of macaque monkeys.

Authors: Tetsuya Sasaki; Yusuke Komatsu; Tetsuo Yamamori
Journal: BMC Res Notes Date: 2020-05-27

4 in total

Slit/Robo Signaling Pathway in Cancer; a New Stand Point for Cancer Treatment.

1. Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription.

Review 2. The role of Slit-Robo signaling in the regulation of tissue barriers.

3. Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : I. Zygotic loci on the second chromosome.

Review 4. Slit-Robo signaling.

5. VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin.

6. Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression.

7. Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis.

8. A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium.

9. Slit-2 induces a tumor-suppressive effect by regulating beta-catenin in breast cancer cells.

10. srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer.

Review 1. The potential of Slit2 as a therapeutic target for central nervous system disorders.

Review 2. Role of Slit/Robo Signaling pathway in Bone Metabolism.

3. miR-152-3p impedes the malignant phenotypes of hepatocellular carcinoma by repressing roundabout guidance receptor 1.

4. Expression patterns of SLIT/ROBO mRNAs reveal a characteristic feature in the entorhinal-hippocampal area of macaque monkeys.