Literature DB >> 28598714

The role of Slit-Robo signaling in the regulation of tissue barriers.

Ming-Fang Wu1,2, Chen-Yi Liao3, Ling-Yi Wang3, Jinghua Tsai Chang2,3.   

Abstract

The role of Slit/Robo signaling has extended from initial axon repulsion in the developing nervous system to organ morphogenesis, cancer development and angiogenesis. Slit/Robo signaling regulates similar pathways within these processes. Slit/Robo ensures the homeostasis of the dynamic interaction between cell-cell and cell-matrix interactions. The dysregulation of Slit/Robo signaling damages the tissue barrier, resulting in developmental abnormalities or disease. Here, we summarize how Slit/Robo controls kidney morphogenesis and describe the dual roles of Slit/Robo signaling in the regulation of tumorigenesis and angiogenesis.

Entities:  

Keywords:  Slit/Robo signaling; alternative splicing; angiogenesis; blood vessel stability; cancer cell migration; cell-cell interaction; endothelial cell permeability; kidney development

Mesh：

Substances：

Year:  2017        PMID： 28598714      PMCID： PMC5501134          DOI： 10.1080/21688370.2017.1331155

Source DB:  PubMed          Journal:  Tissue Barriers        ISSN： 2168-8362


  140 in total

Review 1.  Angiogenesis in the female reproductive system.

Authors:  L P Reynolds; S D Killilea; D A Redmer
Journal:  FASEB J       Date:  1992-02-01       Impact factor: 5.191

Review 2.  A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis.

Authors:  Michael Klagsbrun; Anne Eichmann
Journal:  Cytokine Growth Factor Rev       Date:  2005 Aug-Oct       Impact factor: 7.638

3.  Repulsive axon guidance molecule Slit3 is a novel angiogenic factor.

Authors:  Bing Zhang; Ursula M Dietrich; Jian-Guo Geng; Roy Bicknell; Jeffrey D Esko; Lianchun Wang
Journal:  Blood       Date:  2009-09-09       Impact factor: 22.113

4.  N-cadherin acts in concert with Slit1-Robo2 signaling in regulating aggregation of placode-derived cranial sensory neurons.

Authors:  Celia E Shiau; Marianne Bronner-Fraser
Journal:  Development       Date:  2009-12       Impact factor: 6.868

5.  The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis.

Authors:  I Guijarro-Muñoz; A M Cuesta; A Alvarez-Cienfuegos; J G Geng; L Alvarez-Vallina; L Sanz
Journal:  Exp Cell Res       Date:  2011-12-14       Impact factor: 3.905

6.  Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.

Authors:  Daw-Yang Hwang; Stefan Kohl; Xueping Fan; Asaf Vivante; Stefanie Chan; Gabriel C Dworschak; Julian Schulz; Albertien M van Eerde; Alina C Hilger; Heon Yung Gee; Tracie Pennimpede; Bernhard G Herrmann; Glenn van de Hoek; Kirsten Y Renkema; Christoph Schell; Tobias B Huber; Heiko M Reutter; Neveen A Soliman; Natasa Stajic; Radovan Bogdanovic; Elijah O Kehinde; Richard P Lifton; Velibor Tasic; Weining Lu; Friedhelm Hildebrandt
Journal:  Hum Genet       Date:  2015-05-31       Impact factor: 4.132

7.  ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation.

Authors:  Elanor N Wainwright; Dagmar Wilhelm; Alexander N Combes; Melissa H Little; Peter Koopman
Journal:  Dev Biol       Date:  2015-06-23       Impact factor: 3.582

8.  Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS.

Authors:  S Rajagopalan; V Vivancos; E Nicolas; B J Dickson
Journal:  Cell       Date:  2000-12-22       Impact factor: 41.582

9.  Frequent alterations of SLIT2-ROBO1-CDC42 signalling pathway in breast cancer: clinicopathological correlation.

Authors:  Rittwika Bhattacharya; Nupur Mukherjee; Hemantika Dasgupta; Md Saimul Islam; Neyaz Alam; Anup Roy; Priyobrata Das; Susanta Roychoudhury; Chinmay Kumar Panda
Journal:  J Genet       Date:  2016-09       Impact factor: 1.166

10.  srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer.

Authors:  Yuyang Feng; Lei Feng; Di Yu; Jian Zou; Zhaohui Huang
Journal:  J Exp Clin Cancer Res       Date:  2016-12-07
View more
  5 in total

1.  Morphogenesis of the islets of Langerhans is guided by extra-endocrine Slit2/3 signals.

Authors:  Jennifer M Gilbert; Melissa T Adams; Nadav Sharon; Hariharan Jayaraaman; Barak Blum
Journal:  Mol Cell Biol       Date:  2020-12-14       Impact factor: 4.272

Review 2.  Slit/Robo Signaling Pathway in Cancer; a New Stand Point for Cancer Treatment.

Authors:  Zahra Koohini; Zohreh Koohini; Shahram Teimourian
Journal:  Pathol Oncol Res       Date:  2019-01-04       Impact factor: 3.201

3.  The effects of bone morphogenetic protein 2 and thrombopoietin treatment on angiogenic properties of endothelial cells derived from the lung and bone marrow of young and aged, male and female mice.

Authors:  Ushashi C Dadwal; Fazal Ur Rehman Bhatti; Olatundun D Awosanya; Rohit U Nagaraj; Anthony J Perugini; Seungyup Sun; Conner R Valuch; Caio de Andrade Staut; Stephen K Mendenhall; Nikhil P Tewari; Sarah L Mostardo; Murad K Nazzal; Hanisha L Battina; Donghui Zhou; Deepa Kanagasabapathy; Rachel J Blosser; Patrick L Mulcrone; Jiliang Li; Melissa A Kacena
Journal:  FASEB J       Date:  2021-09       Impact factor: 5.834

4.  A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis.

Authors:  Allison Jevitt; Deeptiman Chatterjee; Gengqiang Xie; Xian-Feng Wang; Taylor Otwell; Yi-Chun Huang; Wu-Min Deng
Journal:  PLoS Biol       Date:  2020-04-27       Impact factor: 8.029

5.  TLE2 is associated with favorable prognosis and regulates cell growth and gemcitabine sensitivity in pancreatic cancer.

Authors:  Shixiong Hu; Zhengbo Chen; Jinling Gu; Liyang Tan; Meifeng Zhang; Weidong Lin
Journal:  Ann Transl Med       Date:  2020-08
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.