Literature DB >> 30606407

Dysregulated Mineral Metabolism in AKI.

David E Leaf1, Marta Christov2.   

Abstract

Dysregulated mineral metabolism is a nearly universal sequalae of acute kidney injury (AKI). Abnormalities in circulating mineral metabolites observed in patients with AKI include hypocalcemia, hyperparathyroidism, hyperphosphatemia, decreased vitamin D metabolite levels, and increased fibroblast growth factor 23 levels. We review the pathophysiology of dysregulated mineral metabolism in AKI with a focus on calcium, phosphate, parathyroid hormone, and vitamin D metabolites. We discuss how mineral metabolite levels can serve as novel prognostic markers for incident AKI and other related outcomes in various clinical settings. Finally, we discuss how vitamin D metabolites potentially could be used as novel therapeutic agents for AKI prevention and treatment.
Copyright © 2018. Published by Elsevier Inc.

Entities:  

Keywords:  AKI; FGF23; PTH; acute kidney injury; calcium; mineral metabolism; phosphate; vitamin D

Mesh：

Substances：

Year:  2019        PMID： 30606407     DOI： 10.1016/j.semnephrol.2018.10.004

Source DB:  PubMed          Journal:  Semin Nephrol        ISSN： 0270-9295            Impact factor:   5.299


  9 in total

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2.  Risk factors for severe acute kidney injury among patients with rhabdomyolysis.

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Review 3.  Acute Kidney Injury and Pediatric Bone Health.

Authors:  Anisha Hegde; Michelle R Denburg; Dorey A Glenn
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4.  Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia-reperfusion acute kidney injury.

Authors:  Danielle E Soranno; Peter Baker; Lara Kirkbride-Romeo; Sara A Wennersten; Kathy Ding; Brysen Keith; Maria A Cavasin; Christopher Altmann; Rushita A Bagchi; Korey R Haefner; John Montford; Katja M Gist; Laurent Vergnes; Karen Reue; Zhibin He; Hanan Elajaili; Kayo Okamura; Eva Nozik; Timothy A McKinsey; Sarah Faubel
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5.  Citrate dose for continuous hemofiltration: effect on calcium and magnesium balance, parathormone and vitamin D status, a randomized controlled trial.

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6.  Fibroblast growth factor-23 and parathyroid hormone suppress small intestinal magnesium absorption.

Authors:  Nasisorn Suksridechacin; Narongrit Thongon
Journal:  Physiol Rep       Date:  2022-04

Review 7.  Molecular Mechanisms and Biomarkers Associated with Chemotherapy-Induced AKI.

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Review 8.  Chronic Kidney Disease as a Systemic Inflammatory Syndrome: Update on Mechanisms Involved and Potential Treatment.

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9.  Machine Learning Model for Risk Prediction of Community-Acquired Acute Kidney Injury Hospitalization From Electronic Health Records: Development and Validation Study.

Authors:  Chien-Ning Hsu; Chien-Liang Liu; You-Lin Tain; Chin-Yu Kuo; Yun-Chun Lin
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  9 in total

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